Study on bursting of pancreatic β cells in codimension-2 bifurcation regions

被引：2

作者：

Yang Zhuo-Qin ^{[1
]}

Guan Ting-Ting ^{[1
]}

Gan Chun-Biao ^{[2
]}

Zhang Jiao-Ying ^{[1
]}

机构：

[1] Beihang Univ, LMIB, Beijing 100083, Peoples R China

[2] Zhejiang Univ, Dept Mech Engn, Hangzhou 310027, Peoples R China

来源：

ACTA PHYSICA SINICA | 2011年 / 60卷 / 11期

基金：

中国国家自然科学基金;

关键词：

bursting; fast/slow analysis; codimension-2; bifurcation; INSULIN-SECRETION; OSCILLATIONS; PATTERNS; SPIKING; CA2+;

D O I：

10.7498/aps.60.110202

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Electrical activities of insulin secretion in pancreatic islets are characterized by bursts of action potentials. With a simple but representative Vries-Sherman model, we determine the regions of different types of bursting in two-parameter plane through the two-parameter bifurcation analysis of the fast subsystem. Moreover, fast/slow analysis is used to reveal topological types of bursting patterns for different values of the parameter Vm and transition mechanisms between them.

引用

页数：6

共 16 条

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