Silica sulfuric acid catalyzed one-pot synthesis of α-aminonitriles

被引：60
|
作者：
Chen, WY
Lu, J
机构：
[1] College of Chemistry and Chemical Engineering, Suzhou University, Suzhou
来源：
SYNLETT | 2005年 / 15期
关键词：
aldehyde; amine; alpha-aminonitrile; silica sulfuric acid; one-pot synthesis;
D O I：
10.1055/s-2005-872654
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient method has been developed for the synthesis of alpha-aminonitriles by a one-Pot three-component condensation of aldehydes, amines, and trimethylsilyl cyanide in the presence of a catalytic amount of silica sulfuric acid at room temperature. The silica sulfuric acid is reusable and could be applied in subsequent reactions with comparable activity.
引用
收藏
页码：2293 / 2296
页数：4
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