Possible prediction of the efficiency of chemotherapy in patients with Lymphoproliferative diseases based on MDR1 gene G2677T and C3435T Polymorphisms

被引：25
|
作者：
Goreva, OB [1 ]
Grishanova, AY
Mukhin, OV
Domnikova, NP
Lyakhovich, VV
机构：
[1] Russian Acad Med Sci, Inst Mol Biol & Biophys, Siberian Div, Novosibirsk, Russia
[2] State Reg Clin Hosp, Novosibirsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2003年 / 136卷 / 02期
关键词：
MDR1/P glycoprotein; genetic polymorphism; lymphoproliferative diseases; drug resistance;
D O I：
10.1023/A:1026331326648
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Study of polymorphism in MDR1 gene exons 21 and 26 revealed that (TT)-T-2677 and (TT)-T-3435 alleles are not a factor predisposing to lymphoproliferative diseases, but they determine the efficiency chemotherapy. Individuals with (TT)-T-2677 and (TT)-T-3435 haplotypes are at highest risk of drug resistance. Association between genotypes G(2677)T and (CT)-T-3435 was detected in normal subjects and in patients with lymphoproliferative diseases.
引用
收藏
页码：183 / 185
页数：3
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