The levels of IL-1β and soluble IL-1 receptors in patients with IgG4-related periaortitis/periarteritis

被引：1
|
作者：
Ashihara, Norihiro [1 ]
Ota, Masao [1 ,4 ]
Fujinaga, Yasunari [2 ]
Ozawa, Makiko [1 ]
Kuraishi, Yasuhiro [1 ]
Watanabe, Takayuki [1 ]
Hamano, Hideaki [1 ]
Joshita, Satoru [1 ]
Kawa, Shigeyuki [3 ]
Umemura, Takeji [1 ]
机构：
[1] Shinshu Univ, Dept Med, Div Gastroenterol & Hepatol, Sch Med, Matsumoto, Japan
[2] Shinshu Univ, Dept Radiol, Sch Med, Matsumoto, Japan
[3] Matsumoto Dent Univ, Dept Internal Med, Shiojiri, Japan
[4] Shinshu Univ, Dept Med, Div Gastroenterol & Hepatol, Sch Med, 3-1-1 Asahi, Matsumoto 3908621, Japan
来源：
ADVANCES IN MEDICAL SCIENCES | 2022年 / 67卷 / 02期
关键词：
IgG4-related periaortitis; periarteritis; IgG4-related disease; IL-18; JAPANESE CONSENSUS GUIDELINES; CYTOTOXIC T-LYMPHOCYTES; AUTOIMMUNE PANCREATITIS; DISEASE; FAMILY; PERIAORTITIS; MECHANISMS; DIAGNOSIS; AMENDMENT; FIBROSIS;
D O I：
10.1016/j.advms.2022.06.003
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Purpose: IgG4-related disease (IgG4-RD) is a chronic fibrotic inflammatory and an immune-mediated disease characterized by high serum IgG4 concentration and IgG4-bearing plasma cell infiltration in affected organs. IgG4-related periaortitis/periarteritis is a recently identified disease entity in IgG4-RD that affects the cardio-vascular system, and its pathogenesis and characteristics remain unclear.The inflammatory cytokine IL-18 is involved in a variety of cellular activities including inflammation, fibrosis, and angiogenesis. The present study compared the levels of the inflammatory cytokine IL-18 and two soluble IL-1 receptors, IL-1R1 and IL-1R2, between IgG4-RD patients with and without IgG4-related periaortitis/periarteritis. Methods: The patients with IgG4-related periaortitis/periarteritis (n = 38), those without (n = 66) and healthy (n = 33) were recruited to measure cytokines of IL-18 and soluble receptors (sIL-1R1 and sIL-1R2) in sera by ELISA assay.Results: Serum IgG4 was significantly higher in patients with periaortitis/periarteritis compared to non-periaortitis/periarteritis (p = 0.0074), while serum IL-18 was significantly lower in patients with periaortitis/ periarteritis (p = 0.00037).The three groups did not show significant difference in sIL1-R1, while sIL-1R2 in the periaortitis/periarteritis and healthy group was higher than in the group without periaortitis/periarteritis (p = 0.00001).Conclusions: The characteristic changes in IL-18, sIL-1R1, and sIL-1R2 levels in IgG4-RD patients with and without IgG4-related periaortitis/periarteritis may indicate an active phase of the inflammatory process in these diseases.
引用
收藏
页码：257 / 261
页数：5
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