Hydrogel film loaded with new formula from manuka honey for treatment of chronic wound infections

Objectives: Chronic wound infections can be effectively treated using hydrogel loaded with an extract from manuka honey. Methods: This study was performed on bacterial isolates from patients with infected wounds at Alexandria Main University Hospital (Alexandria, Egypt). Isolates were exposed to hydrogel sheets composed of chitosan and gelatin and loaded with a new formula from manuka honey. Results: The results illustrate the antibacterial activity of the formula extracted from manuka honey against Staphylococcus aureus, Streptococcus pyogenes, Acinetobacter baumannii, Pseudomonas aeruginosa and Proteus mirabilis. Screening of the hydrogel by electron microscopy showed the ultrastructure of the gel. Conclusions: A hydrogel sheet composed of chitosan and gelatin loaded with a new formula extracted from manuka honey can be used as a dressing for chronic infected wounds. (C) 2017 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.