Metabolism of Classical Cannabinoids and the Synthetic Cannabinoid JWH-018

被引：23
|
作者：
Su, M. K. [1 ]
Seely, K. A. [2 ]
Moran, J. H. [2 ,3 ]
Hoffman, R. S. [1 ]
机构：
[1] NYU, Sch Med, Div Med Toxicol, Ronald O Perelman Dept Emergency Med, New York, NY 10016 USA
[2] Publ Hlth Lab, Arkansas Dept Hlth, Little Rock, AR USA
[3] Univ Arkansas Med Sci, Dept Pharmacol & Toxicol, Coll Med, Little Rock, AR 72205 USA
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2015年 / 97卷 / 06期
关键词：
D O I：
10.1002/cpt.114
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Although the putative pharmacological targets of synthetic cannabinoids (SCBs) abused in "K2" and "Spice" are similar to Delta(9)-tetrahydrocannabinol (Delta(9)-THC), it remains unclear why SCB toxicity is similar yet different from marijuana. There are obvious potency and efficacy differences, but also important metabolic differences that help explain the unique adverse reactions associated with SCBs. This brief review discusses the limited research on the metabolism of the SCB JWH-018 and contrasts that with the metabolism of Delta(9)-THC.
引用
收藏
页码：562 / 564
页数：3
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