Inhibition of WIP1 Phosphatase in Multiple Myeloma Overcomes Bortezomib Resistance and Promotes Cell Death Via ER Stress-Induced Apoptotic JNK/c-jun Signaling and Downregulation of Inhibitors of Apoptosis Proteins (IAPs)

被引：0

作者：

Beider, Katia ^{[1
]}

Rosenberg, Evgenia ^{[1
]}

Voevoda, Valeria ^{[1
]}

Bitner, Hanna ^{[1
]}

Sirovsky, Yaarit ^{[1
]}

Magen, Hila ^{[1
]}

Ostrovsky, Olga ^{[1
]}

Shimoni, Avichai ^{[1
]}

Milyavsky, Michael ^{[2
]}

Peled, Amnon ^{[3
]}

Nagler, Arnon ^{[4
]}

机构：

[1] Chaim Sheba Med Ctr, Div Hematol & Bone Marrow Transplantat, Ramat Gan, Israel

[2] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel

[3] Hebrew Univ Hosp, Goldyne Savad Inst Gene Therapy, Jerusalem, Israel

[4] Chaim Sheba Med Ctr, Dept Hematol, Tel Hashomer, Israel

来源：

BLOOD | 2018年 / 132卷

关键词：

D O I：

10.1182/blood-2018-99-114652

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

1366

引用

页数：4

共 4 条

[1] Blocking of WIP1 Phosphatase Overcomes Bortezomib Resistance and Promotes Cell Death via ER Stress-induced Apoptotic JNK/c-Jun Signaling: Novel Therapeutic Target in Multiple Myeloma
Beider, Katia
Ostrovsky, Olga
Magen, Hila
Shimoni, Avichai
Milyavsky, Michael
Peled, Amnon
Nagler, Arnon
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2019, 19 (10): : E102 - E103
[2] Blocking of Transient Receptor Potential Vanilloid1 (TRPV1) Promotes Lysosomal Destabilization and Enhances Bortezomib-Induced ER Stress and Cell Death Via HSP70 and LAMP3 DownRegulation: Novel Therapeutic Target for Multiple Myeloma
Beider, Katia
Voevoda, Valeria
Bitner, Hanna
Rosenberg, Evgenia
Sirovsky, Yaarit
Magen, Hila
Ostrovsky, Olga
Shimoni, Avichai
Bromberg, Zohar
Peled, Amnon
Nagler, Arnon
BLOOD, 2017, 130
[3] Blocking of Transient Receptor Potential Vanilloid1 (TRPV1) Promotes Lysosomal Destabilization and Enhances Bortezomib-induced ER Stress and Cell Death via HSP70 and LAMP3 Down-regulation: Novel Therapeutic Target for Multiple Myeloma
Beider, Katia
Magen, Hila
Ostrovsky, Olga
Shimoni, Avichai
Peled, Amnon
Nagler, Arnon
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2019, 19 (10): : E103 - E103
[4] K252a prevents nigral Dopaminergic cell death induced by 6-hydroxydopamine through inhibition of both mixed-lineage kinase 3/c-Jun NH2-terminal kinase 3 (JNK3) and apoptosis-inducing kinase 1/JNK3 signaling pathways
Pan, Jing
Wang, Gang
Yang, Hong-Qi
Hong, Zhen
Xiao, Qin
Ren, Jing
Zhou, Hai-Yan
Bai, Li
Chen, Sheng-Di
MOLECULAR PHARMACOLOGY, 2007, 72 (06) : 1607 - 1618

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