Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies

被引:10
|
作者
Moshawih, Said [1 ]
Lim, Ai Fern [1 ]
Ardianto, Chrismawan [2 ]
Goh, Khang Wen [3 ]
Kifli, Nurolaini [1 ]
Goh, Hui Poh [1 ]
Jarrar, Qais [4 ]
Ming, Long Chiau [1 ,2 ]
机构
[1] Univ Brunei Darussalam, PAP Rashidah Saadatul Bolkiah Inst Hlth Sci, BE-1410 Gadong, Brunei
[2] Univ Airlangga, Fac Pharm, Dept Pharm Practice, Surabaya 60115, Indonesia
[3] INTI Int Univ, Fac Data Sci & Informat Technol, Nilai 71800, Negeri Sembilan, Malaysia
[4] Isra Univ, Fac Pharm, Dept Appl Pharmaceut Sci & Clin Pharm, Amman 11622, Jordan
关键词
protein targets; cheminformatics; drug discovery; kinases; chemotherapy; GROWTH-FACTOR RECEPTOR; ISLAND METHYLATOR PHENOTYPE; TYROSINE KINASE INHIBITORS; MICROSATELLITE INSTABILITY; GENETIC ALTERATIONS; DNA-DAMAGE; IDENTIFICATION; PROTEIN; EGFR; PHARMACOPHORE;
D O I
10.3390/biom12070878
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Colorectal cancer is one of the most prevalent cancer types. Although there have been breakthroughs in its treatments, a better understanding of the molecular mechanisms and genetic involvement in colorectal cancer will have a substantial role in producing novel and targeted treatments with better safety profiles. In this review, the main molecular pathways and driver genes that are responsible for initiating and propagating the cascade of signaling molecules reaching carcinoma and the aggressive metastatic stages of colorectal cancer were presented. Protein kinases involved in colorectal cancer, as much as other cancers, have seen much focus and committed efforts due to their crucial role in subsidizing, inhibiting, or changing the disease course. Moreover, notable improvements in colorectal cancer treatments with in silico studies and the enhanced selectivity on specific macromolecular targets were discussed. Besides, the selective multi-target agents have been made easier by employing in silico methods in molecular de novo synthesis or target identification and drug repurposing.
引用
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页数:29
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