Aryl Hydrocarbon Receptor and Cysteine Redox Dynamics Underlie (Mal)adaptive Mechanisms to Chronic Intermittent Hypoxia in Kidney Cortex
被引:9
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作者:
Correia, Maria Joao
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Univ Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, PortugalUniv Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, Portugal
Correia, Maria Joao
[1
]
Pimpao, Antonio B.
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Univ Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, PortugalUniv Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, Portugal
Pimpao, Antonio B.
[1
]
Lopes-Coelho, Filipa
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Univ Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, Portugal
Inst Portugues Oncol Lisboa Francisco Gentil IPOL, Rua Prof Lima Basto, P-1099023 Lisbon, PortugalUniv Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, Portugal
Lopes-Coelho, Filipa
[1
,2
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Sequeira, Catarina O.
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Univ Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, PortugalUniv Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, Portugal
Sequeira, Catarina O.
[1
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Coelho, Nuno R.
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Univ Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, PortugalUniv Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, Portugal
Coelho, Nuno R.
[1
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Goncalves-Dias, Clara
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Univ Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, PortugalUniv Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, Portugal
Goncalves-Dias, Clara
[1
]
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Barouki, Robert
[3
]
Coumoul, Xavier
论文数: 0引用数: 0
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机构:
Univ Paris, INSERM UMR S 1124, 3TS, Environm Tox Therapeut Targets Cellular Signaling, 45 Rue St Peres, F-75006 Paris, FranceUniv Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, Portugal
Coumoul, Xavier
[3
]
Serpa, Jacinta
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Univ Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, Portugal
Inst Portugues Oncol Lisboa Francisco Gentil IPOL, Rua Prof Lima Basto, P-1099023 Lisbon, PortugalUniv Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, Portugal
Serpa, Jacinta
[1
,2
]
Morello, Judit
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Univ Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, PortugalUniv Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, Portugal
Morello, Judit
[1
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Monteiro, Emilia C.
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Univ Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, PortugalUniv Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, Portugal
Monteiro, Emilia C.
[1
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Pereira, Sofia A.
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Univ Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, PortugalUniv Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, Portugal
Pereira, Sofia A.
[1
]
机构:
[1] Univ Nova Lisboa, NOVA Med Sch, CEDOC, P-1169056 Lisbon, Portugal
[2] Inst Portugues Oncol Lisboa Francisco Gentil IPOL, Rua Prof Lima Basto, P-1099023 Lisbon, Portugal
[3] Univ Paris, INSERM UMR S 1124, 3TS, Environm Tox Therapeut Targets Cellular Signaling, 45 Rue St Peres, F-75006 Paris, France
We hypothesized that an interplay between aryl hydrocarbon receptor (AhR) and cysteine-related thiolome at the kidney cortex underlies the mechanisms of (mal)adaptation to chronic intermittent hypoxia (CIH), promoting arterial hypertension (HTN). Using a rat model of CIH-HTN, we investigated the impact of short-term (1 and 7 days), mid-term (14 and 21 days, pre-HTN), and long-term intermittent hypoxia (IH) (up to 60 days, established HTN) on CYP1A1 protein level (a sensitive hallmark of AhR activation) and cysteine-related thiol pools. We found that acute and chronic IH had opposite effects on CYP1A1 and the thiolome. While short-term IH decreased CYP1A1 and increased protein-S-thiolation, long-term IH increased CYP1A1 and free oxidized cysteine. In addition, an in vitro administration of cystine, but not cysteine, to human endothelial cells increased Cyp1a1 expression, supporting cystine as a putative AhR activator. This study supports CYP1A1 as a biomarker of obstructive sleep apnea (OSA) severity and oxidized pools of cysteine as risk indicator of OSA-HTN. This work contributes to a better understanding of the mechanisms underlying the phenotype of OSA-HTN, mimicked by this model, which is in line with precision medicine challenges in OSA.
机构:
Univ Nova Lisboa, Nova Med Sch, Ctr Estudos Doencas Cron, CEDOC,Fac Ciencias Med, Lisbon, PortugalUniv Nova Lisboa, Nova Med Sch, Ctr Estudos Doencas Cron, CEDOC,Fac Ciencias Med, Lisbon, Portugal
Coelho, Nuno R.
Dias, Clara G.
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Univ Nova Lisboa, Nova Med Sch, Ctr Estudos Doencas Cron, CEDOC,Fac Ciencias Med, Lisbon, PortugalUniv Nova Lisboa, Nova Med Sch, Ctr Estudos Doencas Cron, CEDOC,Fac Ciencias Med, Lisbon, Portugal
Dias, Clara G.
Joao Correia, M.
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Univ Nova Lisboa, Nova Med Sch, Ctr Estudos Doencas Cron, CEDOC,Fac Ciencias Med, Lisbon, PortugalUniv Nova Lisboa, Nova Med Sch, Ctr Estudos Doencas Cron, CEDOC,Fac Ciencias Med, Lisbon, Portugal
Joao Correia, M.
Gracio, Patricia
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Univ Nova Lisboa, Nova Med Sch, Ctr Estudos Doencas Cron, CEDOC,Fac Ciencias Med, Lisbon, PortugalUniv Nova Lisboa, Nova Med Sch, Ctr Estudos Doencas Cron, CEDOC,Fac Ciencias Med, Lisbon, Portugal
Gracio, Patricia
Serpa, Jacinta
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机构:
Univ Nova Lisboa, Nova Med Sch, Ctr Estudos Doencas Cron, CEDOC,Fac Ciencias Med, Lisbon, Portugal
IPOLFG, Lisbon, PortugalUniv Nova Lisboa, Nova Med Sch, Ctr Estudos Doencas Cron, CEDOC,Fac Ciencias Med, Lisbon, Portugal
Serpa, Jacinta
Monteiro, Emilia C.
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机构:
Univ Nova Lisboa, Nova Med Sch, Ctr Estudos Doencas Cron, CEDOC,Fac Ciencias Med, Lisbon, PortugalUniv Nova Lisboa, Nova Med Sch, Ctr Estudos Doencas Cron, CEDOC,Fac Ciencias Med, Lisbon, Portugal
Monteiro, Emilia C.
Diogo, Lucilia N.
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Univ Nova Lisboa, Nova Med Sch, Ctr Estudos Doencas Cron, CEDOC,Fac Ciencias Med, Lisbon, PortugalUniv Nova Lisboa, Nova Med Sch, Ctr Estudos Doencas Cron, CEDOC,Fac Ciencias Med, Lisbon, Portugal
Diogo, Lucilia N.
Pereira, Sofia A.
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Univ Nova Lisboa, Nova Med Sch, Ctr Estudos Doencas Cron, CEDOC,Fac Ciencias Med, Lisbon, PortugalUniv Nova Lisboa, Nova Med Sch, Ctr Estudos Doencas Cron, CEDOC,Fac Ciencias Med, Lisbon, Portugal
Pereira, Sofia A.
ARTERIAL CHEMORECEPTORS: NEW DIRECTIONS AND TRANSLATIONAL PERSPECTIVES,
2018,
1071
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机构:
Univ Nova Lisboa, Fac Ciencias Med, Ctr Estudos Doencas Cron, CEDOC,Nova Med Sch, Campo Martires Patria 130, P-1169056 Lisbon, PortugalUniv Nova Lisboa, Fac Ciencias Med, Ctr Estudos Doencas Cron, CEDOC,Nova Med Sch, Campo Martires Patria 130, P-1169056 Lisbon, Portugal
Coelho, Nuno R.
Tomkiewicz, Celine
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Univ Paris, Environm Toxic Therapeut Targets Cellular Signali, INSERM UMR S 1124, 3TS, 45 Rue St Peres, F-75006 Paris, FranceUniv Nova Lisboa, Fac Ciencias Med, Ctr Estudos Doencas Cron, CEDOC,Nova Med Sch, Campo Martires Patria 130, P-1169056 Lisbon, Portugal
Tomkiewicz, Celine
Correia, M. Joao
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Univ Nova Lisboa, Fac Ciencias Med, Ctr Estudos Doencas Cron, CEDOC,Nova Med Sch, Campo Martires Patria 130, P-1169056 Lisbon, PortugalUniv Nova Lisboa, Fac Ciencias Med, Ctr Estudos Doencas Cron, CEDOC,Nova Med Sch, Campo Martires Patria 130, P-1169056 Lisbon, Portugal
Correia, M. Joao
Goncalves-Dias, Clara
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机构:
Univ Nova Lisboa, Fac Ciencias Med, Ctr Estudos Doencas Cron, CEDOC,Nova Med Sch, Campo Martires Patria 130, P-1169056 Lisbon, PortugalUniv Nova Lisboa, Fac Ciencias Med, Ctr Estudos Doencas Cron, CEDOC,Nova Med Sch, Campo Martires Patria 130, P-1169056 Lisbon, Portugal
Goncalves-Dias, Clara
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Barouki, Robert
Pereira, Sofia A.
论文数: 0引用数: 0
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机构:
Univ Nova Lisboa, Fac Ciencias Med, Ctr Estudos Doencas Cron, CEDOC,Nova Med Sch, Campo Martires Patria 130, P-1169056 Lisbon, PortugalUniv Nova Lisboa, Fac Ciencias Med, Ctr Estudos Doencas Cron, CEDOC,Nova Med Sch, Campo Martires Patria 130, P-1169056 Lisbon, Portugal
Pereira, Sofia A.
Coumoul, Xavier
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris, Environm Toxic Therapeut Targets Cellular Signali, INSERM UMR S 1124, 3TS, 45 Rue St Peres, F-75006 Paris, FranceUniv Nova Lisboa, Fac Ciencias Med, Ctr Estudos Doencas Cron, CEDOC,Nova Med Sch, Campo Martires Patria 130, P-1169056 Lisbon, Portugal
Coumoul, Xavier
Monteiro, Emilia C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Nova Lisboa, Fac Ciencias Med, Ctr Estudos Doencas Cron, CEDOC,Nova Med Sch, Campo Martires Patria 130, P-1169056 Lisbon, PortugalUniv Nova Lisboa, Fac Ciencias Med, Ctr Estudos Doencas Cron, CEDOC,Nova Med Sch, Campo Martires Patria 130, P-1169056 Lisbon, Portugal