Classical swine fever virus inhibits nitric oxide production in infected macrophages

被引：22

作者：

Zaffuto, K. M. ^{[1
]}

Piccone, M. E. ^{[1
]}

Burrage, T. G. ^{[1
]}

Balinsky, C. A. ^{[1
]}

Risatti, G. R. ^{[1
]}

Borca, M. V. ^{[1
]}

Holinka, L. G. ^{[1
]}

Rock, D. L. ^{[1
]}

Afonso, C. L. ^{[1
]}

机构：

[1] USDA ARS, Plum Isl Anim Dis Ctr, Greenport, NY 11944 USA

来源：

JOURNAL OF GENERAL VIROLOGY | 2007年 / 88卷

关键词：

D O I：

10.1099/vir.0.83042-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Classical swine fever virus (CSFV)-macrophage interactions during infection were analysed by examining macrophage transcriptional responses via microarray. Eleven genes had increased mRNA levels (> 2.5-fold, P < 0.05) in infected cell cultures, including arginase-1, an inhibitor of nitric oxide production, phosphoinositide 3-kinase, chemokine receptor 4 and interleukin-1 beta Lower levels of nitric oxide and increased arginase activity were found in CSFV-infected macrophages. These changes in gene expression in macrophages suggest viral modulation of host expression to suppress nitric oxide production.

引用

页码：3007 / 3012

页数：6

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