Sulfated Modification of Polysaccharides from Sweet Corncob and Its Antiglycation Activity in Streptozotocin Induced Diabetic Rats

Polysaccharides extracted from sweet corncob (SCP) were modified by sulfuric acid to sulfated sweet corncob (SSCP) with a molecular weight of 13.412 kDa, and their antiglycation activity was studied. SSCP had high inhibitory effects on glycation and showed antiglycation activity stronger than that of SCP in vitro. The maximum inhibition rates of the Amadori products, dicarbonyl compounds, caboxymethyl-lysine (CML), and advanced glycation end products (AGEs) were 76.35, 73.78, 52.79, and 76.36%, respectively. SSCP effectively increased body weight, reduced blood glucose, and increased oral glucose tolerance in streptozotocin (STZ)-induced diabetic rats in vivo. Furthermore, SSCP inhibited AGE formation in liver tissue and repaired pancreatic injury. The results in vivo and in vitro reflect that SSCP has antiglycation effects, which may be closely related to its antidiabetic effects.