CAR-T therapy: Prospects in targeting cancer stem cells

被引:17
|
作者
Cui, Xiaoyue [1 ]
Liu, Rui [2 ]
Duan, Lian [1 ]
Cao, Dan [1 ,3 ]
Zhang, Qiaoling [1 ,3 ]
Zhang, Aijie [1 ]
机构
[1] Suining Cent Hosp, Basic Lab, Suining, Peoples R China
[2] Suining Cent Hosp, Dept Breast & Thyroid Surg, Suining, Peoples R China
[3] Suining Cent Hosp, Key Lab Metab Dis, Suining, Peoples R China
关键词
cancer stem cells; CAR-T; immunotherapy; targeted therapy; CYTOKINE RELEASE SYNDROME; ANTITUMOR-ACTIVITY; INITIATING CELLS; EXPRESSION; GLIOBLASTOMA; HETEROGENEITY; LYMPHOCYTES; GENE; MICROENVIRONMENT; ACTIVATION;
D O I
10.1111/jcmm.16939
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cancer stem cells (CSCs), a group of tumour cells with stem cell characteristics, have the ability of self-renewal, multi-lineage differentiation and tumour formation. Since CSCs are resistant to conventional radiotherapy and chemotherapy, their existence may be one of the root causes of cancer treatment failure and tumour progression. The elimination of CSCs may be effective for eventual tumour eradication. Because of the good therapeutic effects without major histocompatibility complex (MHC) restriction and the unique characteristics of CSCs, chimeric antigen receptor T-cell (CAR-T) therapy is expected to be an important method to eliminate CSCs. In this review, we have discussed the feasibility of CSCs-targeted CAR-T therapy for cancer treatment, summarized current research and clinical trials of targeting CSCs with CAR-T cells and forecasted the challenges and future direction from the perspectives of toxicity, persistence and potency, trafficking, infiltration, immunosuppressive tumour microenvironment, and tumour heterogeneity.
引用
收藏
页码:9891 / 9904
页数:14
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