An efficient stereoselective synthesis of (2S,4S,5R)-(-)- and (2R,4R,5S)-(+)-bulgecinine

被引:16
|
作者
Chavan, SP [1 ]
Praveen, C [1 ]
Sharma, P [1 ]
Kalkote, UR [1 ]
机构
[1] Natl Chem Lab, Div Organ Chem Technol, Pune 411008, Maharashtra, India
关键词
D O I
10.1016/j.tetlet.2004.11.101
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A short synthetic route to (-)-and (+)-bulgecinine, the amino acid moiety of the bulgecins was achieved from the readily available nonchiral pool starting material cis-2-butene-1,4-diol in which a Claisen orthoester rearrangement and a Sharpless asymmetric dihydroxylation were used as the key steps. (C) 2004 Elsevier Ltd. All rights reserved.
引用
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页码:439 / 441
页数:3
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