Omega-3 offers better hypothalamus protection by decreasing POMC expression and elevating ghrelin hormone: a prospective trial to overcome methotrexate-induced anorexia

被引：5

作者：

Mostafa, Heba ^{[1
]}

Barakat, Lamia ^{[1
]}

Abdo, Walied S. ^{[2
]}

Khalil, Rania M. ^{[3
]}

机构：

[1] Port Said Univ, Fac Sci, Biochem Dept, Port Said, Egypt

[2] Kafrelsheik Univ, Fac Vet Med, Pathol Dept, Kafr Elsheik 33516, Egypt

[3] Delta Univ Sci & Technol, Fac Pharm, Biochem Dept, Gamasa, Egypt

来源：

ENDOCRINE | 2020年 / 69卷 / 02期

关键词：

Methotrexate; Anorexia; Omega-3; Ghrelin; Taste buds; POMC gene; CISPLATIN-INDUCED ANOREXIA; BODY-WEIGHT; OXIDATIVE STRESS; NEUROPEPTIDE-Y; FOOD-INTAKE; CHEMOTHERAPY; CANCER; POMEGRANATE; RIKKUNSHITO; DYSFUNCTION;

D O I：

10.1007/s12020-020-02342-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose Methotrexate (MTX) therapy is widely used in treatment of different types of diseases including inflammatory diseases, autoimmune disorders, and cancer. However, most of patients respond well to MTX, they suffer from multiple side effects including severe anorexia. Omega-3 fatty acid possesses many beneficial biological activities. Therefore, the objective of our study is to explore the effect of the combined modality of omega-3 (400 mg/kg/day) in MTX-induced anorexia in rats. Methods The effect of MTX alone and in combination with omega-3 on the body weight, ghrelin hormone level, histopathological findings of taste buds and hypothalamus and POMC gene expression were investigated. Results Interestingly, the capability of omega-3 to overcome the anorexic effect of MTX could be manifested by controlling weight loss, increasing serum HDL, elevating the ghrelin level as well as reducing both lesions within taste buds and hypothalamus and hypothalamic POMC gene expression. Conclusions our findings revealed that the omega-3 might be used as a complementary supplement during the MTX therapy to ameliorate its anorexic effect.

引用

页码：358 / 367

页数：10