A study of the reaction between 2,4-disubstituted-2,3-dihydro-1,5-benzothiazepines and ketenes generated in situ from chloro and dichloroacetyl chlorides

被引：3
|
作者：
Xing, QY
Wang, HZ [1 ]
Zhou, X
Jin, S
Li, YM
Chan, ASC
机构：
[1] Peking Univ, Sch Chem & Mol Engn, Beijing 100871, Peoples R China
[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2001年 / 38卷 / 03期
关键词：
D O I：
10.1002/jhet.5570380302
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In the presence of triethyl amine, the reaction of 2,4-disubstituted-2,3-dihydro- 1,5-benzothiazepine with chloro and dichloroacetyl chlorides produced not only the expected beta -lactam derivative of the benzothiazepine, but also the ring opening product. Different results were obtained when the substituent at 2-position of the bexuothiazepine varied from methyl to aryl, and the substituent on the chloroacetyl chloride varied from H to Cl, or when carrying out the reaction at different temperatures. The structures of the obtained products and the reaction mechanism are discussed.
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收藏
页码：561 / 567
页数：7
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