INVOLVEMENT OF ATAXIA TELANGIECTASIA MUTATED (ATM) SIGNALING PATHWAYS IN ACETAMINOPHEN (APAP)-INDUCED HEPATOTOXICITY OFFERS THERAPEUTIC OPPORTUNITIES FOR ACUTE LIVER FAILURE (ALF)

被引：0
|
作者：
Viswanathan, Preeti [1 ,2 ]
Bandi, Sriram [2 ]
Simon, Jeannette Gonzalez [1 ]
Gupta, Sanjeev [2 ]
机构：
[1] Childrens Hosp Montefiore, Bronx, NY USA
[2] Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Bronx, NY 10467 USA
来源：
HEPATOLOGY | 2011年 / 54卷
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
引用
收藏
页码：366A / 366A
页数：1
相关论文
共 23 条
  • [1] Reversal of Ataxia Telangiectasia Mutated (ATM) Signaling Pathway-associated DNA Damage and Acute Liver Failure (ALF) Following Acetaminophen (APAP) Toxicity by Hepatic Support from Extrahepatically Transplanted Hepatocytes
    Viswanathan, Preeti
    Bandi, Sriram
    Gupta, Sanjeev
    HEPATOLOGY, 2012, 56 : 967A - 968A
  • [2] Ataxia-Telangiectasia Mutated (ATM) gene signaling pathways in human cancers and their therapeutic implications
    Varadhan, Varsha
    Manikandan, Monica Shri
    Nagarajan, Akshaya
    Palaniyandi, Thirunavukkarasu
    Ravi, Maddaly
    Sankareswaran, Senthil Kumar
    Baskar, Gomathy
    Wahab, Mugip Rahaman Abdul
    Surendran, Hemapreethi
    PATHOLOGY RESEARCH AND PRACTICE, 2024, 260
  • [3] Comments on "Clinically relevant therapeutic approaches against acetaminophen (APAP) hepatotoxicity and acute liver failure"
    Karlsson, Jan Olof G.
    Jynge, Per
    BIOCHEMICAL PHARMACOLOGY, 2024, 225
  • [4] RESTORATION OF DEFICIENT CYTOKINES INDUCING STAT3 AND ATM SIGNALING REACTIVATE CELL INTERACTIONS FOR LIVER REGENERATION (LR) IN ACETAMINOPHEN (APAP)-INDUCED ACUTE LIVER FAILURE (ALF)
    Viswanathan, Preeti
    Sharma, Yogeshwar
    Jaber, Fadi-Luc
    Gupta, Sanjeev
    HEPATOLOGY, 2021, 74 : 733A - 733A
  • [5] Apparent increasing incidence of acetaminophen (APAP)-induced acute liver failure (ALF) in the United States.
    Larson, AM
    Polson, J
    Fontana, RJ
    Davern, T
    Lalani, E
    Shakil, AO
    Lee, WM
    HEPATOLOGY, 2004, 40 (04) : 497A - 497A
  • [6] Characterization of hepatic encephalopathy (HE) in an acetaminophen (APAP) induced acute liver failure (ALF) mouse model
    Ten Have, GAM
    Van den Heuvel, MGW
    Blokland, A
    Jalan, R
    Deutz, NEP
    FASEB JOURNAL, 2005, 19 (05): : A1048 - A1048
  • [7] Gene Therapy with Candidate microRNAs (miRNA) Capable of Regulating DNA Damage Response Rescues Mice with Acetaminophen (APAP)- induced Acute Liver Failure (ALF) and Offers New Therapeutic Directions
    Viswanathan, Preeti
    Sharma, Yogeshwar
    Bandi, Sriram
    Gupta, Sanjeev
    HEPATOLOGY, 2016, 64 : 317A - 317A
  • [8] Transcriptional profiling reveals an aberrant hepatic regenerative response underlying acetaminophen (APAP)-induced acute liver failure (ALF)
    Rogler, Leslie
    Pattamanuch, Nicole
    Bandi, Sriram
    Viswanathan, Preeti
    Gupta, Sanjeev
    FASEB JOURNAL, 2014, 28 (01):
  • [9] REPLENISHING DEFICIENT CYTOKINES IN ACUTE LIVER FAILURE (ALF) RESTORES DNA DAMAGE RESPONSE THROUGH ATAXIA TELANGIECTASIA MUTATED (ATM) AND STAT3 PATHWAY INTERSECTIONS
    Viswanathan, Preeti
    Sharma, Yogeshwar
    Maisuradze, Luka
    Jaber, Fadi-Luc
    Tchaikovskaya, Tatyana
    Gupta, Sanjeev
    HEPATOLOGY, 2020, 72 : 140A - 140A
  • [10] Replicative Stress and Cell Cycle Restriction in G0/G1 Following Genomic DNA Damage and Disruption of ATM Signaling Accounts for Failure of Liver Regeneration and Offers Therapeutic Directions in Acetaminophen (APAP)-induced Acute Liver Failure
    Viswanathan, Preeti
    Sharma, Yogeshwar
    Bandi, Sriram
    Gupta, Sanjeev
    HEPATOLOGY, 2015, 62 : 1068A - 1069A
123