Effects of extensive splenomegaly in patients with myelofibrosis undergoing a reduced intensity allogeneic stem cell transplantation

被引：43
|
作者：
Ciurea, Stefan O. [1 ]
Sadegi, Barry [2 ]
Wilbur, Andrew [2 ]
Alagiozian-Angelova, Victoria [3 ]
Gaitonde, Sujata [3 ]
Dobogai, Lisa C. [1 ]
Akard, Luke P. [4 ]
Hoffman, Ronald [5 ]
Rondelli, Damiano [1 ]
机构：
[1] Univ Illinois, Hematol Oncol Sect, Coll Med, Div Hematol,Dept Med, Chicago, IL 60612 USA
[2] Univ Illinois, Coll Med, Dept Radiol, Chicago, IL 60612 USA
[3] Univ Illinois, Coll Med, Div Hematopathol, Dept Pathol, Chicago, IL 60612 USA
[4] Indiana Blood & Marrow Transplantat Program, Indianapolis, IN USA
[5] Mt Sinai Sch Med, Hematol Oncol Sect, New York, NY USA
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2008年 / 141卷 / 01期
关键词：
myeloproliferative disorder; splenomegaly; reduced-intensity conditioning stem cell transplantation; myelofibrosis;
D O I：
10.1111/j.1365-2141.2008.07010.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Changes in spleen size postallogeneic haematopoietic stem cell transplantation (HSCT) in patients with primary myelofibrosis have been poorly characterized. We analysed 10 patients with myelofibrosis and splenomegaly following a reduced-intensity allogeneic HSCT. All patients fully engrafted donor cells including five patients with extensive splenomegaly. Extensive splenomegaly was associated with a prolonged time to neutrophil and platelet recovery. In all 10 patients, a progressive reduction of splenomegaly was documented within 12 months post-transplant and paralleled the reduction of marrow fibrosis. These findings suggest that myelofibrosis patients with extensive splenomegaly may proceed with allogeneic HSCT without prior splenectomy.
引用
收藏
页码：80 / 83
页数：4
相关论文
共 50 条
  • [1] ROLE OF EXTENSIVE SPLENOMEGALY IN PATIENTS WITH MYELOFIBROSIS UNDERGOING A REDUCED INTENSITY ALLOGENEIC STEM CELL TRANSPLANT
    Ciurea, S. O.
    Sadegi, B.
    Wilbur, A.
    Alagiozian-Angelova, V.
    Gaitonde, S.
    Dobogai, L.
    Akard, L. P.
    Hoffman, R.
    Rondelli, D.
    [J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2008, 14 (02) : 112 - 112
  • [2] Is splenectomy necessary in patients with myelofibrosis and extensive splenomegaly prior to allogeneic stem cell transplantation with reduced intensity conditioning regimens?
    Ciurea, Stefan O.
    Sadegi, Barry
    Wilbur, Andrew
    Alagiozian-Angelova, Victoria
    Gaitonde, Sujata
    Dobogai, Lisa C.
    Akard, Luke P.
    Hoffman, Ronald
    Rondelli, Damiano
    [J]. BLOOD, 2007, 110 (11) : 331A - 331A
  • [3] Reduced intensity allogeneic stem cell transplantation in patients with myelofibrosis
    Bloor, AJC
    Ahmed, O
    Dimpoulou, M
    Fielding, AK
    Chakraverty, R
    Parker, AN
    Liakopoulou, E
    Goldstone, AH
    Thomson, K
    Mackinnon, S
    Kottaridis, P
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2006, 133 : 13 - 13
  • [4] Reduced Intensity Allogeneic Stem Cell Transplantation for Younger Patients with Myelofibrosis
    Mannina, Daniele
    Wolschke, Christine
    Zabelina, Tatjana
    Zeck, Gaby
    von Pein, Ute-Marie
    Ayuk, Francis Ayuketang
    Kroeger, Nicolaus
    [J]. BLOOD, 2018, 132
  • [5] Reduced intensity allogeneic stem cell transplantation for younger patients with myelofibrosis
    Mannina, Daniele
    Zabelina, Tatjana
    Wolschke, Christine
    Heinzelmann, Marion
    Triviai, Ioanna
    Christopeit, Maximilian
    Badbaran, Anita
    Bonmann, Stefan
    von Pein, Ute-Marie
    Janson, Dietlinde
    Ayuk, Francis
    Kroeger, Nicolaus
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 2019, 186 (03) : 484 - 489
  • [6] Reduced intensity allogeneic stem cell transplantation for younger patients with myelofibrosis
    Mannina, Daniele
    Wolschke, Christine
    Zabelina, Tatjana
    Zeck, Gaby
    von Pein, Ute-Marie
    Ayuk, Francis
    Kroeger, Nicolaus
    [J]. BONE MARROW TRANSPLANTATION, 2019, 54 : 198 - 199
  • [7] Myelofibrosis and reduced intensity allogeneic hematopoietic stem cell transplantation (RISCT)
    Popat, Uday R.
    Rondon, Gabriela
    Alousi, Amin M.
    Anderlini, Paolo
    Andersson, Borje S.
    De Lima, Marcos J.
    Giralt, Sergio A.
    Hosing, Chitra M.
    Kebriaei, Partow
    Jones, Roy
    Nieto, Yago
    Shpall, Elizabeth J.
    Verstovesek, Srdan
    Qazilbash, Muzaffar H.
    Champlin, Richard
    [J]. BLOOD, 2007, 110 (11) : 900A - 900A
  • [8] NONMYELOABLATIVE AND REDUCED INTENSITY CONDITIONING IN ALLOGENEIC STEM CELL TRANSPLANTATION FOR MYELOFIBROSIS
    Malone, A. K.
    Scigliano, E.
    Grosskreutz, C.
    Osman, K.
    Isola, L.
    [J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2010, 16 (02) : S285 - S285
  • [9] The Role of Spleen Directed Therapy and Predictors of Outcomes with Reduced Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Primary Myelofibrosis and Splenomegaly
    Partain, Daniel K.
    Damlaj, Moussab
    Al -Kali, Aref
    Gangat, Naseema
    Litzow, Mark R.
    Hogan, William J.
    Hashmi, Shahrukh K.
    Gonsalves, Wilson I.
    Foran, James M.
    Roy, Vivek
    Mesa, Ruben A.
    Palmer, Jeanne
    Slack, James L.
    Patnaik, Mrinal M.
    [J]. BLOOD, 2015, 126 (23)
  • [10] Pilot study of reduced-intensity conditioning followed by allogeneic stem cell transplantation in patients with myelofibrosis
    Kroeger, N
    Zabelina, T
    Schieder, H
    Panse, J
    Ayuk, F
    Fehse, N
    Fehse, B
    Waschke, O
    Kvasnicka, HM
    Thiele, J
    Zander, A
    [J]. BLOOD, 2004, 104 (11) : 423A - 423A
12345