Bile Composition as a Diagnostic and Prognostic Tool in Liver Transplantation

被引：36
|
作者：
Bruggenwirth, Isabel M. A. [1 ,2 ]
Porte, Robert J. [2 ]
Martins, Paulo N. [1 ]
机构：
[1] Univ Massachusetts, Div Organ Transplantat, Dept Surg, UMass Mem Med Ctr, 55 North Lake Ave, Worcester, MA 01655 USA
[2] Univ Med Ctr Groningen, Dept Surg, Sect Hepatobiliary Surg & Liver Transplantat, Groningen, Netherlands
来源：
LIVER TRANSPLANTATION | 2020年 / 26卷 / 09期
关键词：
NORMOTHERMIC MACHINE PERFUSION; ACUTE CELLULAR REJECTION; DUCT INJURY; BILIARY STRICTURES; LIPID-COMPOSITION; SALT TOXICITY; DONOR LIVERS; PRESERVATION; SECRETION; COMPLICATIONS;
D O I：
10.1002/lt.25771
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Bile secretion and composition reflects the functional status of hepatocytes and cholangiocytes. Bile composition can have a role in the assessment of donor grafts before implantation in the recipient. In addition, changes in bile composition after liver transplantation can serve as a diagnostic and prognostic tool to predict posttransplant complications, such as primary nonfunction, acute cellular rejection, or nonanastomotic biliary strictures. With the popularization of liver machine perfusion preservation in the clinical setting, there is a revisited interest in biliary biomarkers to assess graft viability before implantation. This review discusses current literature on biliary biomarkers that could predict or assess liver graft and bile duct viability. Bile composition offers an exciting and novel perspective in the search for reliable hepatocyte and cholangiocyte viability biomarkers.
引用
收藏
页码：1177 / 1187
页数：11
相关论文
共 50 条
  • [1] PROTEIN BIOMARKERS IN BILE AS A DIAGNOSTIC TOOL AFTER LIVER TRANSPLANTATION
    Schmuck, R. B.
    Reutzel-Selke, A.
    Raschzok, N.
    Lippert, S.
    Morgul, M. H.
    Puhl, G.
    Seehofer, D.
    Bahra, M.
    Lojewski, C.
    Pascher, A.
    Neuhaus, P.
    Pratschke, J.
    Sauer, I. M.
    TRANSPLANT INTERNATIONAL, 2014, 27 : 39 - 39
  • [2] Mirna Pattern Within the Bile as a Diagnostic Tool after Liver Transplantation
    Schmuck, R. B.
    Raschzok, N.
    Reutzel-Selke, A.
    Lippert, S.
    Koenig, S.
    Prabowo, K. A.
    Morgul, M. H.
    Tannus, L. M.
    Jonas, S.
    Neuhaus, P.
    Sauer, I. M.
    TRANSPLANTATION, 2012, 94 (10) : 95 - 95
  • [3] BILE COMPOSITION AND BILE CAST FORMATION AFTER TRANSPLANTATION OF LIVER IN MAN
    WALDRAM, R
    WILLIAMS, R
    CALNE, RY
    TRANSPLANTATION, 1975, 19 (05) : 382 - 387
  • [4] COMPOSITION OF BILE AFTER ORTHOTOPIC LIVER-TRANSPLANTATION
    HAAGSMA, EB
    HUIZENGA, JR
    VONK, RJ
    ALBERS, CJEM
    GROND, J
    KROM, RAF
    GIPS, CH
    SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1987, 22 (09) : 1049 - 1055
  • [5] BILE COMPOSITION AND BILE CAST FORMATION AFTER LIVER-TRANSPLANTATION IN MAN
    MCMASTER, P
    HERBERTSON, BM
    CALNE, RY
    WILLIAMS, R
    CUSICK, C
    GUT, 1977, 18 (05) : A403 - A403
  • [6] BILE COMPOSITION AND BILE CAST FORMATION AFTER LIVER-TRANSPLANTATION IN MAN
    MCMASTER, P
    CUSICK, C
    HERBERTSON, B
    CALNE, RY
    WILLIAMS, R
    EUROPEAN SURGICAL RESEARCH, 1977, 9 : 107 - 107
  • [7] STUDIES OF BILE COMPOSITION AFTER LIVER-TRANSPLANTATION IN MAN
    MCMASTER, P
    CUSICK, C
    HERBERTSON, BM
    WILLIAMS, R
    CALNE, RY
    GASTROENTEROLOGY, 1978, 74 (05) : 1157 - 1157
  • [8] Biliary lipid secretion rates and bile acid composition in bile after liver transplantation
    Einarsson, KA
    Angelin, B
    Ericzon, BG
    BILE ACIDS AND IMMUNOLOGY, 1996, 86 : 47 - 56
  • [9] Pediatric liver re-transplantation: Prognostic scoring tool
    Kuehne, Alexander
    Vock, David
    Larson-Nath, Catherine
    Chinnakotla, Srinath
    PEDIATRIC TRANSPLANTATION, 2019, 23
  • [10] Pediatric liver re-transplantation: Prognostic scoring tool
    Kuehne, Alexander
    Vock, David
    Larson-Nath, Catherine
    Chinnakotla, Srinath
    PEDIATRIC TRANSPLANTATION, 2019, 23
12345