Integrins put the brakes on microcluster dynamics at the immunological synapse

被引：4
|
作者：
Burkhardt, Janis K. [1 ,2 ]
机构：
[1] Childrens Hosp Philadelphia, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Philadelphia, PA 19104 USA
来源：
IMMUNITY | 2008年 / 28卷 / 06期
关键词：
D O I：
10.1016/j.immuni.2008.05.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Integrin engagement costimulates T cell receptor signaling, but the underlying mechanisms are poorly understood. In this issue of Immunity, Nguyen et al. (2008) show that engagement of VLA-4 promotes sustained signaling by altering the dynamics of actin filaments and signaling molecules at the immunological synapse.
引用
收藏
页码：732 / 734
页数：3
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