Perinatal Exposure to Tartrazine Triggers Oxidative Stress and Neurobehavioral Alterations in Mice Offspring

被引:21
|
作者
Albasher, Gadah [1 ]
Maashi, Najla [1 ]
Alfarraj, Saleh [1 ]
Almeer, Rafa [1 ]
Albrahim, Tarfa [2 ]
Alotibi, Fatimah [3 ]
Bin-Jumah, May [4 ]
Mahmoud, Ayman M. [5 ]
机构
[1] King Saud Univ, Coll Sci, Dept Zool, Riyadh 11451, Saudi Arabia
[2] Princess Nourah Bint Abdulrahman Univ Riyadh, Coll Hlth & Rehabil Sci, Dept Hlth Sci, Clin Nutr, Riyadh 84428, Saudi Arabia
[3] King Saud Univ, Coll Sci, Dept Bot & Microbiol, Riyadh 11451, Saudi Arabia
[4] Princess Nourah Bint Abdulrahman Univ, Coll Sci, Dept Biol, Riyadh 84428, Saudi Arabia
[5] Beni Suef Univ, Fac Sci, Zool Dept, Physiol Div, Bani Suwayf 62514, Egypt
关键词
azo dyes; neurotoxicity; food colorants; oxidative stress; E102; FOOD AZO DYES; HEMATOLOGICAL ALTERATIONS; BEHAVIOR; INFLAMMATION; ADDITIVES; BRAIN; LIVER; ASSAY; ACID; RATS;
D O I
10.3390/antiox9010053
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The use of synthetic azo dyes as coloring agents in food products has dramatically increased. This study evaluated the effect of perinatal exposure to tartrazine (TZ) on mice offspring, focusing on neurobehavioral alterations and oxidative stress. The female mice received TZ (2.5 and 5 mg/kg) via oral gavage during pregnancy and the first 15 days after birth. At days 21 and 35 after birth, male mice were sacrificed, and samples were collected for analyses. Perinatal exposure to TZ triggered tissue injury evidenced by the histological alterations and neuronal damage in the cerebrum, medulla oblongata, and cerebellum. TZ provoked lipid peroxidation and diminished cellular antioxidants in different brain regions of the newborns. In addition, TZ increased hemoglobin content, as well as erythrocytes, leukocytes, and platelets count at days 21 and 35 after birth. Both the locomotor behavior and anxiety reflex were significantly altered in mice exposed to TZ. In conclusion, perinatal exposure to TZ within an adequate daily intake range induced oxidative stress and neurobehavioral and hematological alterations in mice offspring. Therefore, consuming foods containing TZ during pregnancy and lactation warrants public awareness.
引用
收藏
页数:14
相关论文
共 50 条
  • [1] In utero exposure to tobacco and alcohol modifies neurobehavioral development in mice offspring: consideration a role of oxidative stress
    Li, Y
    Wang, H
    [J]. PHARMACOLOGICAL RESEARCH, 2004, 49 (05) : 467 - 473
  • [2] Paternal valproic acid exposure in mice triggers behavioral alterations in offspring
    Ibi, Daisuke
    Fujiki, Yu
    Koide, Nayu
    Nakasai, Genki
    Takaba, Rika
    Hiramatsu, Masayuki
    [J]. NEUROTOXICOLOGY AND TERATOLOGY, 2019, 76
  • [3] Celery ameliorating against neurobehavioral and neurochemical disorders of perinatal lipopolysaccharides exposure in mice offspring
    Abu-Taweel, Gasem Mohammad
    [J]. JOURNAL OF KING SAUD UNIVERSITY SCIENCE, 2020, 32 (02) : 1764 - 1771
  • [4] Perinatal exposure to energy drink induces oxidative damage in the liver, kidney and brain, and behavioral alterations in mice offspring
    Al-Basher, Gadh I.
    Aljabal, Hanan
    Almeer, Rafa S.
    Allam, Ahmed A.
    Mahmoud, Ayman M.
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2018, 102 : 798 - 811
  • [5] Camellia sinensis Prevents Perinatal Nicotine-Induced Neurobehavioral Alterations, Tissue Injury, and Oxidative Stress in Male and Female Mice Newborns
    Ajarem, Jamaan S.
    Al-Basher, Gadh
    Allam, Ahmed A.
    Mahmoud, Ayman M.
    [J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2017, 2017
  • [6] Perinatal morphine but not buprenorphine affects gestational and offspring neurobehavioral outcomes in mice
    Smith, Brittany L.
    Hassler, Ally
    Lloyd, Kelsey R.
    Reyes, Teresa M.
    [J]. NEUROTOXICOLOGY, 2023, 99 : 292 - 304
  • [7] Developmental and neurobehavioral effects of perinatal exposure to polychlorinated biphenyls in mice
    Sugawara, N
    Nakai, K
    Nakamura, T
    Ohba, T
    Suzuki, K
    Kameo, S
    Satoh, C
    Satoh, H
    [J]. ARCHIVES OF TOXICOLOGY, 2006, 80 (05) : 286 - 292
  • [8] Developmental and neurobehavioral effects of perinatal exposure to polychlorinated biphenyls in mice
    Norio Sugawara
    Kunihiko Nakai
    Tomoyuki Nakamura
    Takashi Ohba
    Keita Suzuki
    Satomi Kameo
    Chieko Satoh
    Hiroshi Satoh
    [J]. Archives of Toxicology, 2006, 80 : 286 - 292
  • [9] Low cadmium exposure triggers a biphasic oxidative stress response in mice kidneys
    Thijssen, Sandy
    Cuypers, Ann
    Maringwa, John
    Smeets, Karen
    Horemans, Nele
    Lambrichts, Ivo
    Van Kerkhove, Emmy
    [J]. TOXICOLOGY, 2007, 236 (1-2) : 29 - 41
  • [10] Inulin alleviates neuroinflammation and oxidative stress induced by perinatal 2-ethylhexyl diphenyl phosphate (EHDPHP) exposure in female mice and offspring
    Li, Xiu-Wen
    Qiu, Feng
    Liu, Yi
    Chen, Li-Jian
    Li, Jia-Hao
    Liu, Jia-Li
    Yang, Jian-Zheng
    Hsu, Clare
    Chen, Long
    Zeng, Jia-Hao
    Xie, Xiao-Li
    Wang, Qi
    [J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2023, 264