Hugo (ugo) Schiff, Schiff bases, and a century of β-lactam synthesis

被引：196
|
作者：
Tidwell, Thomas T. [1 ]
机构：
[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 06期
关键词：
2+2] cycloaddition; beta-lactams; history of chemistry; ketenes; Schiff bases;
D O I：
10.1002/anie.200702965
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Schiff - the man and the base: Hugo Schiff (1834-1915) studied with Friedrich Wohler in Germany, but because of his liberal views spent almost his entire career in Italy, where he prepared and characterized Schiff bases (imines) and made many other chemical investigations. His scientific career spanned more than 60 years, and he lived to see the utilization of Schiff bases in [2+2] cycloadditions with ketenes to form β-lactams. (Figure Presented). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
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页码：1016 / 1020
页数：5
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