A Genetic Comparison of Brucella abortus Isolates from Animals and Humans by Using an MLVA Assay

被引：9
|
作者：
Her, Moon [1 ,2 ]
Kang, Sung-Il [1 ,2 ]
Kim, Jong-Wan [1 ,2 ]
Kim, Ji-Yeon [1 ,2 ]
Hwang, In-Yeong [1 ,2 ]
Jung, Suk-Chan [1 ,2 ]
Park, Sang Hee [3 ]
Park, Mi Yeoun [3 ]
Yoo, Hansang [4 ]
机构：
[1] NVRQS, Vet Res Dept, Bacteriol & Parasitol Div, OIE Reference Lab Brucellosis, Anyang 430824, South Korea
[2] NVRQS, Vet Res Dept, Bacteriol & Parasitol Div, Zoonosis Lab, Anyang 430824, South Korea
[3] Korea Ctr Dis Control & Prevent KCDC, Div Zoonoses, Ctr Immunol & Pathol, Natl Inst Hlth, Seoul 122701, South Korea
[4] Seoul Natl Univ, KRF Zoonot Dis Prior Res Inst, Dept Infect Dis, Coll Vet Med, Seoul 151747, South Korea
来源：
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 2010年 / 20卷 / 12期
关键词：
Brucella abortus; MLVA; epidemiology; animal; human; TANDEM-REPEAT ANALYSIS; STRAIN; OUTBREAK; SEALS;
D O I：
10.4014/jmb.1005.05039
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The MLVA assay is known to have a high ability to identify and discriminate Brucella species, so that it can be used as an epidemiological tool to discriminate Brucella isolates originating from restricted geographic sources. In this study, the genetic profiles of 38 B. abortus isolates from humans were analyzed and compared with genotypes from animal isolates in South Korea. As a result, it was found that they did not show high genetic diversity and were compacted. They were clustered together with animal isolates, showing a significant correlation to regional distributions. With its ability to prove a significant genetic correlation among B. abortus isolates from animals and humans in South Korea, the MLVA assay could be utilized as part of a program to control and eradicate brucellosis, one of the major zoonoses. This study represents the first data of genetic correlation of B. abortus isolates from humans and animals in South Korea.
引用
收藏
页码：1750 / 1755
页数：6
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