Objective: To examine racial/ethnic differences in the relationship between weight perception and weight management behaviors among overweight and obese adults. Participants: The study examined a nationally representative sample of 11,319 non-Hispanic White, non-Hispanic Black and Mexican American overweight and obese adults aged >= 20 years from the 1999-2006 National Health and Nutrition Examination Survey. Design: Body mass index (BMI, defined as weight in kilograms divided by height in meters squared) was used to categorize overweight (25 <= BMI<30) and obesity (BMI >= 30). Measured height and weight were used to calculate BMI. Subjects reported self-perception of weight status (correct perception and misperception) and weight management behaviors over the previous 12 months (trying to lose weight, trying not to gain weight, and having a desired weight goal). Weight perception stratified logistic regression was used to model odds of weight management behavior by race/ethnicity. Results: Among overweight and obese non-Hispanic White, non-Hispanic Black, and Mexican American adults, correct weight perception was positively associated with weight management behavior. In multiple logistic regression models, overweight non-Hispanic Blacks with a weight misperception were less likely to have tried to lose weight (adjusted odds ratio [aOR]=.7; 95% confidence interval [CI]=.5,1.0) or to have tried not to gain weight (aOR=.7; 95% CI =.5,1.0) compared to overweight non-Hispanic Whites with a weight misperception. Among the obese with a misperception, non-Hispanic Blacks were less likely to desire to weigh less compared to non-Hispanic Whites (aOR=.5; 95% CI=.3,.9). Conclusions: Weight perception was associated with weight management behaviors, and this relationship varied by race/ethnicity. Weight perception may need to be addressed among overweight and obese individuals to increase appropriate weight management behaviors, particularly among minority communities. (Ethn Dis. 2010;20:244-250)