Antibacterial activities of some plant extracts alone and in combination with different antimicrobials against multidrug-resistant Pseudomonas aeruginosa strains

被引：56
作者：
Adwan, Ghaleb [1 ]
Abu-Shanab, Bassam [2 ]
Adwan, Kamel [1 ]
机构：
[1] An Najah N Univ, Dept Biol & Biotechnol, Nablus, Israel
[2] An Najah N Univ, Fac Vet Med, Nablus, Israel
来源：
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE | 2010年 / 3卷 / 04期
关键词：
Synergism; Rhus coriaria; Sacropoterium spinosum; Rosa damascena; Medicinal plants; Antimicrobial agents; Pseudomonas aeruginosa; Palestine;
D O I：
10.1016/S1995-7645(10)60064-8
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Objective: To evaluate the possible in vitro interaction between ethanolic extracts of Rhus coriaria (R. coriaria) (seed), Sacropoterium spinosum (S. spinosum) (seed), Rosa damascena (R. damascene) (flower) and certain known antimicrobial drugs including oxytetracycline HCl, penicillin G, cephalexin, sulfadimethoxine as sodium, and enrofloxacin. This synergy study was carried out against 3 clinical strains of multidrug-resistant Pseudomonas aeruginosa (P. aeruginosa). Methods: Evaluation of synergy interaction between plant extracts and antimicrobial agents was carried out using microdilution method. Results: The results of this study showed that there is a decrease in the MIC in case of combination of ethanolic plant extracts and test antimicrobial agents. The most interesting result was that the combination between R. coriaria and these antibiotics, showed a high decrease in minimum inhibitory concentration (MIC), and a strong bactericidal activity against these strains. Conclusions: These results may indicate that combinations between R. coriaria extract and these antibiotics could be useful in fighting emerging drug-resistance P. aeruginosa, which may due to that R. coriaria extract contain natural inhibitors working by different mechanisms or inhibiting efflux pumps. Now we have experiments underway leading to the identification of the active molecules present in R. coriaria. Further, in vivo experiments are needed to confirm pseudomonal protection. © 2010 Hainan Medical College.
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页码：266 / 266
页数：1
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