Relationship Between Plasma Pentraxin 3 Concentration and Platelet Indices in Patients With Stable Coronary Artery Disease

被引:2
|
作者
Korzonek-Szlacheta, Ilona [1 ]
Danikiewicz, Aleksander [1 ]
Szkodzinski, Janusz [2 ]
Nowak, Justyna [1 ]
Lekston, Andrzej [2 ]
Gasior, Mariusz [2 ]
Zubelewicz-Szkodzinska, Barbara [1 ]
Hudzik, Bartosz [1 ,2 ]
机构
[1] Med Univ Silesia, Fac Publ Hlth, Dept Nutr Related Dis Prevent, Bytom, Poland
[2] Med Univ Silesia, SMDZ Zabrze, Silesian Ctr Heart Dis, Dept Cardiol 3, Zabrze, Poland
关键词
pentraxin; 3; platelet indices; mean platelet volume; platelet distribution width; platelet to lymphocyte ratio; mean platelet volume to lymphocyte ratio; coronary artery disease; TO-LYMPHOCYTE RATIO; C-REACTIVE PROTEIN; DIABETES-MELLITUS; UNSTABLE ANGINA; PTX3; INFLAMMATION; MARKER; VOLUME; ATHEROSCLEROSIS; PROGNOSIS;
D O I
10.1177/0003319717732929
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Few reports have analyzed the effect of pentraxin 3 (PTX3) on platelets and their activation. We explored the association between plasma PTX3 and platelet indices. Forty-nine patients with stable coronary artery disease (CAD) were enrolled. Based on median PTX3, the study population was divided into group 1 (n = 25; PTX3 0.98 ng/mL) and group 2 (n = 24; PTX3 > 0.98 ng/mL). Platelet indices investigated included mean platelet volume (MPV), platelet distribution width (PDW), platelets and large cell ratio (P-LCR), MPV to platelet count ratio (MPV/PC), platelet to lymphocyte ratio (PLR), and MPV to lymphocyte ratio (MPVLR). Patients with lower PTX3 had a higher lymphocyte count. Platelet count was similar in both groups. Notwithstanding, patients with higher PTX3 concentrations had elevated MPV (8.3 vs 10.0 fL; P < .001) and PDW (9.4 vs 12.4 fL; P < .001). However, the MPV/PC ratio was similar in both groups. Thromboinflammatory biomarkers (PLR, MPVLR) were also elevated in group 2. Pentraxin 3showed a strong, positive correlation with MPV (r = .75, P < .01) and PDW (r = .80, P < .01), and weak to moderate correlation with MPVLR. In conclusion, PTX3 is associated with larger platelet size as assessed by platelet volume indices. There is a strong correlation between plasma PTX3 level and MPV and PDW.
引用
收藏
页码:264 / 269
页数:6
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