Synthesis of novel spiropyrrolizidines as potent antimicrobial agents for human and plant pathogens

被引：115
|
作者：
Periyasami, Govindasami [1 ]
Raghunathan, Raghavachary [1 ]
Surendiran, Gangadharan [2 ]
Mathivanan, Narayanasamy [2 ]
机构：
[1] Univ Madras, Dept Organ Chem, Madras 600025, Tamil Nadu, India
[2] Univ Madras, Ctr Adv Studies Bot, Madras 600025, Tamil Nadu, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 07期
关键词：
1,3-dipolar cycloaddition; azomethine ylide; microwave; pyrrolizidine;
D O I：
10.1016/j.bmcl.2008.02.065
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of novel dispirooxindolopyrrolizidine derivatives have been synthesized through 1,3-dipolar cycloaddition reaction of azomethine ylide generated from proline and isatin with the dipolarophile (E)-2-arylidine-1-keto carbazoles. The synthesized cycloadducts were evaluated for antimicrobial activities. Compounds 7d and 7e showed relatively good antibacterial and antifungal activities. (C) 2008 Elsevier Ltd. All rights reserved.
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收藏
页码：2342 / 2345
页数：4
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