The Drosophila gene twister, an orthologue of the yeast helicase SKI2, is differentially expressed during development

被引：10
|
作者：
Seago, JE [1 ]
Chernukhin, IV [1 ]
Newbury, SF [1 ]
机构：
[1] Univ Oxford, Dept Biochem, Genet Unit, Oxford OX1 3QU, England
来源：
MECHANISMS OF DEVELOPMENT | 2001年 / 106卷 / 1-2期
基金：
英国生物技术与生命科学研究理事会;
关键词：
Drosophila developments; RNA stability; messenger RNA degradation; ribonucleases; gene regulation; SKI2;
D O I：
10.1016/S0925-4773(01)00429-4
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We have identified and characterized a Drosophila orthologue of SK12, which, in Saccharomyces cerevisiae. is one of the key components in the cytoplasmic 3 ' -5 ' decay of mRNA. The Drosophila orthologue (twister, tst), is expressed as two transcripts which differ in the lengths of their 3 ' -UTRs, with the smaller transcript being particularly abundant in 0-2 h embryos and the larger transcript reaching its highest levels in 6-8 h embryos. TST protein is expressed in two forms which are differentially expressed in adult tissues and throughout development. Differential expression of TST may modulate activity of the mRNA turnover pathway and could have a major impact on the expression of target RNAs. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：137 / 141
页数：5
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