Epstein-Barr virus;
carcinoma;
breast;
immunohistochemistry;
in situ hybridization;
D O I:
10.1684/abc.2008.0191
中图分类号:
R446 [实验室诊断];
R-33 [实验医学、医学实验];
学科分类号:
1001 ;
摘要:
Objective: the purpose of our work is to detect Epstein-Barr virus (EBV) in 2 types of breast cancer: medullary carcinoma and high grade invasive ductal carcinoma with lymphoid stroma. Patients and methods: we proceeded to a retrospective study of 18 medullary carcinoma and 18 high grade invasive ductal carcinoma with lymphoid stroma. The detection of the virus was carried out by immunohistochemistry with anti-LMP2 antibody and by hybridization in situ by oligonucleotides EBER1 and EBER1 LMP1 as well as hybridization in situ were positive in 5 tumors (3 medullary carcinoma and 2 high grade invasive ductal carcinoma with lymphoid stroma). Results: positivity was observed in tumor cells and neither in epithelial non tumoral ones nor in lymphoid cells. Discussion and conclusions: during numerous years, correlations between the replication of EBV and the appearance of a malignant phenotype were limited to nasopharyngeal carcinoma and to lymphoid cells. A controversy regarding the association of EBV with breast cancers has recently been reported in the literature. This cancer being very frequent, the involvement of EBV even in a small proportion of breast cancers could have important implications. Our results suggest a possible implication of EBV in these tumours but other studies are necessary.
机构:
Univ Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South Korea
Lee, Jeong Hoon
Son, Da Hye
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机构:
Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South Korea
Son, Da Hye
Ahn, Ji Yong
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机构:
Univ Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South Korea
Ahn, Ji Yong
Choi, Kwi-Sook
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Univ Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South Korea
Choi, Kwi-Sook
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Kim, Do Hoon
Choi, Kee Don
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机构:
Univ Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South Korea
Choi, Kee Don
Song, Ho June
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Univ Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South Korea
Song, Ho June
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机构:
Lee, Gin Hyug
Jung, Hwoon-Yong
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Univ Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South Korea
Jung, Hwoon-Yong
Kim, Jin-Ho
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Univ Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South Korea
Kim, Jin-Ho
Yook, Jeong Hwan
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机构:
Univ Ulsan, Coll Med, Asan Med Ctr, Dept Surg, Seoul, South KoreaUniv Ulsan, Coll Med, Asan Med Ctr, Dept Gastroenterol, Seoul, South Korea