Detection of Epstein-Barr virus in breast cancers with lymphoid stroma

被引:11
|
作者
Trabelsi, A. [1 ]
Rammeh, S. [1 ]
Stita, W. [1 ]
Mokni, M. [1 ]
Mourou, A. [1 ]
Korbi, S. [1 ]
机构
[1] CHU Farhat Hached, Lab Anat & Cytol Pathol, Sousse, Tunisia
关键词
Epstein-Barr virus; carcinoma; breast; immunohistochemistry; in situ hybridization;
D O I
10.1684/abc.2008.0191
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Objective: the purpose of our work is to detect Epstein-Barr virus (EBV) in 2 types of breast cancer: medullary carcinoma and high grade invasive ductal carcinoma with lymphoid stroma. Patients and methods: we proceeded to a retrospective study of 18 medullary carcinoma and 18 high grade invasive ductal carcinoma with lymphoid stroma. The detection of the virus was carried out by immunohistochemistry with anti-LMP2 antibody and by hybridization in situ by oligonucleotides EBER1 and EBER1 LMP1 as well as hybridization in situ were positive in 5 tumors (3 medullary carcinoma and 2 high grade invasive ductal carcinoma with lymphoid stroma). Results: positivity was observed in tumor cells and neither in epithelial non tumoral ones nor in lymphoid cells. Discussion and conclusions: during numerous years, correlations between the replication of EBV and the appearance of a malignant phenotype were limited to nasopharyngeal carcinoma and to lymphoid cells. A controversy regarding the association of EBV with breast cancers has recently been reported in the literature. This cancer being very frequent, the involvement of EBV even in a small proportion of breast cancers could have important implications. Our results suggest a possible implication of EBV in these tumours but other studies are necessary.
引用
收藏
页码:59 / 62
页数:4
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