Mitochondrial-Derived Peptides in Diabetes and Its Complications

被引：19

作者：

Wu, Ying ^{[1
]}

Sun, Liankun ^{[1
]}

Zhuang, Zhoudao ^{[2
]}

Hu, Xiaoqing ^{[3
]}

Dong, Delu ^{[1
]}

机构：

[1] Jilin Univ, Key Lab Pathobiol, Minist Educ, Dept Pathophysiol,Coll Basic Med Sci, Changchun, Peoples R China

[2] Jilin Univ, Clin Med Coll, First Hosp Jilin Univ, Changchun, Peoples R China

[3] First Hosp Jilin Univ, Dept Ophthalmol, Changchun, Peoples R China

来源：

FRONTIERS IN ENDOCRINOLOGY | 2022年 / 12卷

基金：

中国国家自然科学基金;

关键词：

mitochondrial-derived peptides (MDPs); humanin; MOTS-c; stroke; myocardial infarction; diabetes; MOTS-C; OXIDATIVE STRESS; RESCUE FACTOR; CELL-DEATH; HUMANIN; COMPLEX; INFLAMMATION; HOMEOSTASIS; METABOLISM; APOPTOSIS;

D O I：

10.3389/fendo.2021.808120

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The changes of mitochondrial function are closely related to diabetes and its complications. Here we describe the effects of mitochondrial-derived peptides (MDPs), short peptides formed by transcription and translation of the open reading frame site in human mitochondrial DNA (mtDNA), on diabetes and its complications. We mainly focus on MDPs that have been discovered so far, such as Humanin (HN), mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) and Small humanin-like peptides (SHLP 1-6), and elucidated the role of MDPs in diabetes and its major complications stroke and myocardial infarction by improving insulin resistance, inhibiting inflammatory response and anti-apoptosis. It provides more possibilities for the clinical application of mitochondrial derived peptides.

引用

页数：7

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