L-propionylcarnitine inhibits superoxide anion production by human platelets

被引：0

作者：

Pignatelli, P ^{[1
]}

Lenti, L ^{[1
]}

Caroselli, C ^{[1
]}

Frati, G ^{[1
]}

Simeoni, I ^{[1
]}

Gazzaniga, PP ^{[1
]}

Pulcinelli, FM ^{[1
]}

Violi, F ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Ist Terapia Med Sistemat, I-00185 Rome, Italy

来源：

HEART DISEASE: NEW TRENDS IN RESEARCH, DIAGNOSIS AND TREATMENT | 2001年

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the effect of 1-propionylcarnitine, a cellular constituent that plays a role in phospholipid metabolism, on oxygen free radicals produced by human platelets. L-propionylcarnitine was able to inhibit dose-dependently platelet response to agonists such as collagen or arachidonic acid. Moreover, 1-propionylcarnitine induced a reduced release of C-14-arachidonic acid by platelets stimulated with exogenously added arachidonic acid or collagen. We also assessed oxygen free radicals production by cultured endothelial cells incubated with 1-propionylcarnitine. L-propionylcarnitine (10-50 muM) inhibited O-2(-) production by endothelial cells stimulated with lipopolysaccharide and significantly reduced the increase of O-2(-) observed in endothelial cells that had undergone anoxia-reoxygenation.

引用

页码：45 / 49

页数：5

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