Objectively measured physical activity and kidney function in older men; a cross-sectional population-based study

被引:26
|
作者
Parsons, Tessa J. [1 ]
Sartini, Claudio [1 ]
Ash, Sarah [1 ]
Lennon, Lucy T. [1 ]
Wannamethee, S. Goya [1 ]
Lee, I-Min [2 ]
Whincup, Peter H. [3 ]
Jefferis, Barbara J. [1 ]
机构
[1] UCL Med Sch, UCL Dept Primary Care & Populat Hlth, London NW3 2PF, England
[2] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02215 USA
[3] St Georges Univ London, Populat Hlth Res Inst, Cranmer Terrace, London SW17 0RE, England
关键词
older people; physical activity; kidney function; sedentary behaviour; glomerular filtration rate; GLOMERULAR-FILTRATION-RATE; RENAL-FUNCTION; CARDIOVASCULAR MORTALITY; SEDENTARY BEHAVIOR; ASSOCIATION; EXERCISE; DISEASE; COHORT; TIME; AGE;
D O I
10.1093/ageing/afx091
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background: kidney function declines in older adults and physical activity levels are low. We investigated whether higher levels of physical activity and lower levels of sedentary behaviour were associated with lower odds of low kidney function in older men. Methods: cross-sectional study of 1,352 men from the British Regional Heart Study, mean (standard deviation) age 78.5 (4.6) year. Physical activity and sedentary behaviour were measured using Actigraph GT3X accelerometers. Kidney function was measured by estimated Glomerular filtration rate (eGFR) using the chronic kidney disease-EPI creatinine-cystatin equation. Associations between physical (in) activity and kidney function were investigated using regression models. Results: higher levels of physical activity and lower levels of sedentary behaviour were associated with reduced odds ratios (ORs) for lower eGFR (<45 versus >= 45 ml/min per 1.73 m(2)) after adjustment for covariates. Each additional 1,000 steps, 30 min of light physical activity and 10 min of moderate/vigorous physical activity per day were associated with a lower odds (95% confidence interval (CI)) of a low eGFR; OR 0.81 (0.73, 0.91), OR 0.87 (0.78, 0.97) and OR 0.84 (0.76, 0.92), respectively. Each additional 30 min of sedentary behaviour per day was associated with a higher odds of a low eGFR (1.16 95% CI 1.06, 1.27). Associations between moderate/vigorous physical activity and lower kidney function persisted after adjustment for light physical activity or sedentary behaviour. Conclusion: physical activity is associated with kidney function in older men and could be of public health importance in this group who are at increased risk of poor kidney function and low physical activity. More evidence is needed on whether the association is causal.
引用
收藏
页码:1010 / 1014
页数:6
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