Microproteins: a 3D protein structure prediction analysis

被引：1
|
作者：
Thambu, Kishan [1 ]
Glomb, Victoria [1 ]
Trapero, Rolando Hernandez [1 ]
Facelli, Julio C. [1 ,2 ]
机构：
[1] Univ Utah, Dept Biomed Informat, Salt Lake City, UT 84112 USA
[2] Univ Utah, Clin & Translat Sci Inst, Salt Lake City, UT USA
来源：
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS | 2022年 / 40卷 / 24期
关键词：
Gene ontology; ligand binding sites; microproteins; protein structure; protein structure prediction; CASP; DISCOVERY; NETWORKS;
D O I：
10.1080/07391102.2021.1993343
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Microproteins are a novel and expanding group of small proteins encoded by less than 100-150 codons that are translated from small open reading frames (smORFs). It has been shown that smORFs and their corresponding microproteins make up a sizable fraction of the genome and proteome, but very little information on microproteins' structural features exists in the literature. In this paper, we present the results of analyzing the predicted structures of 44 microproteins. The results show that this set of microproteins have a different amino acid composition profiles, similar structural characteristics and fewer small-molecule ligand binding sites than regular proteins.
引用
收藏
页码：13738 / 13746
页数：9
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