Plasma glutamine status at intensive care unit admission: an independent risk factor for mortality in critical illness

被引:10
|
作者
Smedberg, Marie [1 ,2 ]
Helleberg, Johan [1 ,2 ]
Norberg, Ake [1 ,2 ]
Tjader, Inga [1 ,2 ]
Rooyackers, Olav [1 ,2 ]
Wernerman, Jan [1 ,2 ]
机构
[1] Karolinska Univ Hosp Huddinge, Karolinska Inst, Dept Anaesthesiol & Intens Care, CLINTEC, B31 Perioperat Med & Intens Care, S-14186 Stockholm, Sweden
[2] Karolinska Univ Hosp Huddinge, Perioperat Med & Intens Care, Karolinska Univ Hosp Huddinge Stockholm, B31 Perioperat Med & Intens Care, S-14186 Stockholm, Sweden
基金
英国医学研究理事会;
关键词
Plasma glutamine; Critical illness; Hyperglutaminemia; Mortality; Liver failure; ILL PATIENTS; AMINO-ACIDS; AMMONIA; MUSCLE; ANTIOXIDANTS; METABOLISM; DEPLETION; PATIENT;
D O I
10.1186/s13054-021-03640-3
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Background A plasma glutamine concentration outside the normal range at Intensive Care Unit (ICU) admission has been reported to be associated with an increased mortality rate. Whereas hypoglutaminemia has been frequently reported, the number of patients with hyperglutaminemia has so far been quite few. Therefore, the association between hyperglutaminemia and mortality outcomes was studied in a prospective, observational study. Patients and methods Consecutive admissions to a mixed general ICU were eligible. Exclusion criteria were < 18 years of age, readmissions, no informed consent, or a 'do not resuscitate' order at admission. A blood sample was saved within one hour from admission to be analysed by high-pressure liquid chromatography for glutamine concentration. Conventional risk scoring (Simplified Acute Physiology Score and Sequential Organ Failure Assessment) at admission, and mortality outcomes were recorded for all included patients. Results Out of 269 included patients, 26 were hyperglutaminemic (>= 930 mu mol/L) at admission. The six-month mortality rate for this subgroup was 46%, compared to 18% for patients with a plasma glutamine concentration < 930 mu mol/L (P = 0.002). A regression analysis showed that hyperglutaminemia was an independent mortality predictor that added prediction value to conventional admission risk scoring and age. Conclusion Hyperglutaminemia in critical illness at ICU admission was an independent mortality predictor, often but not always, associated with an acute liver condition. The mechanism behind a plasma glutamine concentration outside normal range, as well as the prognostic value of repeated measurements of plasma glutamine during ICU stay, remains to be investigated.
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页数:9
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