Constructing confidence intervals for selected parameters

被引:4
|
作者
Zhao, Haibing [1 ]
Cui, Xinping [2 ,3 ]
机构
[1] Shanghai Univ Finance & Econ, Sch Stat & Management, Shanghai, Peoples R China
[2] Univ Calif Riverside, Dept Stat, Ctr Plant Cell Biol, Riverside, CA 92521 USA
[3] Univ Calif Riverside, Inst Integrat Genome Biol, Riverside, CA 92521 USA
基金
中国国家自然科学基金; 美国国家科学基金会;
关键词
BH procedure; confidence level; false coverage-statement rate; selective confidence interval; FALSE DISCOVERY RATE; GENE-EXPRESSION; PROPORTION; NULL; HYPOTHESES; POWER;
D O I
10.1111/biom.13222
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In large-scale problems, it is common practice to select important parameters by a procedure such as the Benjamini and Hochberg procedure and construct confidence intervals (CIs) for further investigation while the false coverage-statement rate (FCR) for the CIs is controlled at a desired level. Although the well-known BY CIs control the FCR, they are uniformly inflated. In this paper, we propose two methods to construct shorter selective CIs. The first method produces shorter CIs by allowing a reduced number of selective CIs. The second method produces shorter CIs by allowing a prefixed proportion of CIs containing the values of uninteresting parameters. We theoretically prove that the proposed CIs are uniformly shorter than BY CIs and control the FCR asymptotically for independent data. Numerical results confirm our theoretical results and show that the proposed CIs still work for correlated data. We illustrate the advantage of the proposed procedures by analyzing the microarray data from a HIV study.
引用
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页码:1098 / 1108
页数:11
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