Immune senescence, epigenetics and autoimmunity

被引：115
|
作者：
Ray, Donna [1 ]
Yung, Raymond [2 ]
机构：
[1] Univ Michigan, Dept Internal Med, Div Rheumatol, Michigan Med, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Internal Med, Div Geriatr & Palliat Med, Michigan Med, Ann Arbor, MI 48109 USA
来源：
CLINICAL IMMUNOLOGY | 2018年 / 196卷
关键词：
Immune senescence; Inflammation; Autoimmunity; Epigenetics; TUMOR-NECROSIS-FACTOR; REGULATORY T-CELLS; NF-KAPPA-B; CHAIN FATTY-ACIDS; RHEUMATOID-ARTHRITIS; PERIPHERAL-BLOOD; CELLULAR SENESCENCE; DNA METHYLATION; AGE; ACTIVATION;
D O I：
10.1016/j.clim.2018.04.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Aging of the immune system in humans and animals is characterized by a decline in both adaptive and innate immune responses. Paradoxically, aging is also associated with a state of chronic inflammation ("inflammaging") and an increased likelihood of developing autoimmune diseases. Epigenetic changes in non-dividing and dividing cells, including immune cells, due to environmental factors contribute to the inflammation and auto immunity that characterize both the state and diseases of aging. Here, we review the epigenetic mechanisms involved in the development of immune senescence and autoimmunity in old age.
引用
收藏
页码：59 / 63
页数：5
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