Incidence trends of vulvar squamous cell carcinoma in Italy from 1990 to 2015

被引：20

作者：

Mancini, Silvia ^{[1
]}

Bucchi, Lauro ^{[1
]}

Baldacchini, Flavia ^{[1
]}

Giuliani, Orietta ^{[1
]}

Ravaioli, Alessandra ^{[1
]}

Vattiato, Rosa ^{[1
]}

Preti, Mario ^{[2
]}

Tumino, Rosario ^{[3
]}

Ferretti, Stefano ^{[4
]}

Biggeri, Annibale ^{[5
]}

Brustolin, Angelita ^{[6
]}

Boschetti, Lorenza ^{[7
]}

Caiazzo, Anna L. ^{[8
]}

Caldarella, Adele ^{[9
]}

Cesaraccio, Rosaria ^{[10
]}

Cirilli, Claudia ^{[11
]}

Citarella, Annarita ^{[12
]}

Filiberti, Rosa A. ^{[13
]}

Fusco, Mario ^{[14
]}

Galasso, Rocco ^{[15
]}

Gatti, Luciana ^{[16
]}

Lotti, Fernanda L. ^{[17
]}

Magoni, Michele ^{[18
]}

Mangone, Lucia ^{[19
]}

Masanotti, Giuseppe ^{[20
,21
]}

Mazzoleni, Guido ^{[22
]}

Mazzucco, Walter ^{[23
]}

Melcarne, Anna ^{[24
]}

Michiara, Maria ^{[25
]}

Pesce, Paola ^{[26
]}

Piffer, Silvano ^{[27
]}

Pinto, Angela ^{[28
]}

Rognoni, Magda ^{[29
]}

Rosso, Stefano ^{[30
]}

Rugge, Massimo ^{[31
]}

Sampietro, Giuseppe ^{[32
]}

Santo Scalzi ^{[33
]}

Scuderi, Tiziana ^{[34
]}

Tagliabue, Giovanna ^{[35
]}

Tisano, Francesco ^{[36
]}

Toffolutti, Federica ^{[37
]}

Vitarelli, Susanna ^{[38
]}

Falcini, Fabio ^{[1
,39
]}

机构：

[1] Ist Sci Romagnolo Studio & Cura Tumori IRST IRCCS, Romagna Canc Inst, Meldola, Forli, Italy

[2] Univ Torino, Dept Obstet & Gynaecol, Turin, Italy

[3] Prov Hlth Author ASP, Canc Registry & Histopathol Dept, Ragusa, Italy

[4] Univ Ferrara, Local Hlth Author, Ferrara, Italy

[5] Univ Florence, Dept Stat, Applicat G Parenti, Comp Sci, Florence, Italy

[6] Local Hlth Author, Unit Epidemiol & Canc Registry, Viterbo, Italy

[7] Publ Hlth Agcy Pavia, Pavia Canc Registry, Pavia, Italy

[8] Canc Registry Local Hlth Author Salerno, Salerno, Italy

[9] Inst Canc Res Prevent & Clin Network ISPRO, Clin & Descript Epidemiol Unit, Tuscany Canc Registry, Florence, Italy

[10] Azienda Reg Tutela Salute ATS, Sassari Canc Registry, Sassari, Italy

[11] Local Hlth Author, Publ Hlth Dept, Modena Canc Registry, Modena, Italy

[12] Local Hlth Author, Unit Epidemiol, Canc Registry, Dept Prevent, Benevento, Italy

[13] IRCCS Osped Policlin San Martino, Liguria Canc Registry, Genoa, Italy

[14] Napoli 3 Sud Canc Registry, Naples, Italy

[15] IRCCS CROB, Clin Epidemiol & Biostat, Unit Reg Canc Registry, Basilicata, Rionem In Vultu, Italy

[16] Agenzia Tutela Salute ATS Val Padana, Epidemiol Unit, Mantova Canc Registry, Mantua, Italy

[17] Brindisi Canc Registry, Local Hlth Author, Brindisi, Italy

[18] Brescia Hlth Protect Agcy, Epidemiol Unit, Canc Registry Brescia Prov, Brescia, Italy

[19] Azienda Unita Sanitaria Locale IRCCS Reggio Emili, Epidemiol Unit, Via Amendola 2, I-42122 Reggio Emilia, Italy

[20] Univ Perugia, Dept Expt Med, Sect Publ Hlth, Perugia, Italy

[21] Univ Perugia, Dept Expt Med, RTUP Register, Perugia, Italy

[22] South Tyrol Tumor Registry, Bolzano, Italy

[23] Univ Palermo, Dept Hlth Promot Maternal & Infant Care Internal, Palermo, Italy

[24] Lecce Prov Canc Registry, Lecce, Italy

[25] Univ Hosp Parma, Med Oncol Unit, Parma Canc Registry, Parma, Italy

[26] Catania Messina & Enna Canc Registry, Catania, Italy

[27] Trento Prov Canc Registry, Unit Clin Epidemiol, Trento, Italy

[28] Barletta Andria Trani Canc Registry, Barletta, Italy

[29] Hlth Protect Agcy, Epidemiol Unit, Canc Registry ATS Brianza, Monza, Italy

[30] AOU Citta Salute & Sci Torino, Piedmont Canc Registry, Turin, Italy

[31] Univ Padova DIMED, Azienda Zero, Veneto Tumour Registry, Padua, Italy

[32] ATS Bergamo, Bergamo Canc Registry, Bergamo, Italy

[33] Catanzaro Asp Canc Registry, Catanzaro, Italy

[34] Trapani & Agrigento Canc Registry, Trapani, Italy

[35] Fdn IRCCS Ist Nazl Tumori, Dept Res, Canc Registry Unit, Lombardy Canc Registry Varese Prov, Milan, Italy

[36] Canc Registry Prov Siracusa, Siracusa, Italy

[37] Ctr Riferimento Oncol Aviano CRO IRCCS, Canc Epidemiol Unit, Aviano, Italy

[38] Univ Camerino, Macerata Prov Canc Registry, Camerino, Italy

[39] Local Hlth Author, Canc Prevent Unit, Forli, Italy

来源：

GYNECOLOGIC ONCOLOGY | 2020年 / 157卷 / 03期

关键词：

Vulvar neoplasms; Incidence; Trend; Age-period-cohort modelling; CANCER INCIDENCE; AGE-PERIOD; INTRAEPITHELIAL NEOPLASIA; TEMPORAL VARIATION; SURVIVAL; MORTALITY; WOMEN; RATES; RISK; SMOKING;

D O I：

10.1016/j.ygyno.2020.03.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective. The incidence of vulvar squamous cell carcinoma has increased for decades inmostWestern countries - a trend virtually restricted towomen aged <50 or 60 years. In southern Europe, conversely, the trends have been insufficiently studied. This article reports a study from Italy. Method. Thirty-eight local cancer registries, currently covering 15,274,070 women, equivalent to 49.2% of the Italian national female population, participated. Invasive cancers registered between 1990 and 2015 with an International Classification of Diseases for Oncology, 3rd revision, topography code C51 and morphology codes compatible with vulvar squamous cell carcinoma (n = 6294) were eligible. Incidence trends were analysed using joinpoint regression models, with calculation of the estimated annual percent change (EAPC), and age-period-cohort models. Results. Total incidence showed a regular and significant decreasing trend (EAPC, -0.96; 95% confidence interval (CI), -1.43 to -0.48). This was entirely accounted for by women aged >= 60 years (EAPC, -1.34; 95% CI, -1.86 to -0.81). For younger women, the EAPC between 1990 and 2012 was 1.20 (95% CI, 0.34 to 2.06) with a non-significant acceleration thereafter. This pattern did not vary substantially in a sensitivity analysis for the effect of geographic area and duration of the registry. The age-period-cohort analysis revealed a risk decrease in cohorts born between 1905 and 1940 and a new increase in cohorts born since 1945. Conclusions. The decreasing trend observed among olderwomen and the resulting decrease in total rate are at variancewith reports from most Western countries. Age-period-cohort analysis confirmed a decreasing trend for earliest birth cohorts and an opposite one for recent ones. (C) 2020 Elsevier Inc. All rights reserved.

引用

页码：656 / 663

页数：8

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