AIDS in Africa: the impact of coinfections on the pathogenesis of HIV-1 infection

被引：90
|
作者：
Lawn, SD [1 ]
机构：
[1] St George Hosp, Sch Med, Dept Cellular & Mol Sci Infect Dis, London SW17 0RE, England
来源：
JOURNAL OF INFECTION | 2004年 / 48卷 / 01期
基金：
英国惠康基金;
关键词：
HIV-1; AIDS; pathogenesis; Africa; immune activation; disease progression; coinfections; viral load;
D O I：
10.1016/j.jinf.2003.09.001
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The intimate relationship between the HIV-1 life-cycle and the activation state of cells supporting viral replication results in a dynamic interaction between coinfections and HIV-1 replication in dually infected people. The immunologic impact of recurrent coinfections has the potential to increase viral replication, viral genotypic heterogeneity and CD4 T lymphocyte loss, leading to accelerated decline in immune function, reduced survival and increased HIV-1 transmission risk. These effects may play a particularly significant role in the HIV-1 epidemic in sub-Saharan Africa. The mechanisms underlying these effects on virus-host dynamics are reviewed and data describing the impact of tuberculosis, malaria, schistosomiasis and genital ulceration on HIV-1 infection are presented. (C) 2003 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
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页码：1 / 12
页数：12
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