Copper-based metal coordination complexes with Voriconazole ligand: Syntheses, structures and antimicrobial properties

Three new chiral metal coordination complexes, namely, [Cu(FZ)(2)(CH3COO)(2)(H2O)}center dot 2H(2)O (1), [Cu(FZ)(2)(NO3)(2)] (2), and [Cu-2(FZ)(2) (H2O)(8)](SO4)(2)center dot 4H(2)O (3) [FZ = (2R,3S)-2-(2,4-difluoropheny1)-3-(5-fluoro-4-pyrimidiny)-1-(1H-1,2,4-triazol-1-yl)-2-butanol) (Voriconazole)] have been obtained by the reaction of Cu(II) salts and the free ligand FZ at room temperature. Complexes 1-3 were structurally characterized by Xray single-crystal diffraction, IR, UV-vis, powder X-ray diffraction (PXRD), and thermogravimetric analysis (TGA). Complex 1 crystallizes in the chiral space group C-2, which exhibits a mono-nuclear structure. Both complexes 2 and 3 display a one-dimensional (1D) tape structure, which crystallize in chiral space group P2(1)2(1)2 and P2(1)2(1)2(1), respectively. Among these complexes, there exist a variety of hydrogen bonds and stacking interactions, through which a three-dimensional supramolecular architecture will be generated. Compared with the standard (Voriconazole), these Cu-based complexes show the more potent inhibiting efficiency against the species of Candida and Aspergillus. Moreover, among these complexes, complex 1 shows the most excellent efficiency.