Development of gut microbiota along with its metabolites of preschool children

被引：14
|
作者：
Xiong, Jingjing [1 ]
Hu, Hongwei [1 ]
Xu, Chuanzhi [2 ]
Yin, Jianwen [3 ]
Liu, Mei [1 ]
Zhang, Lizhi [1 ]
Duan, Yong [4 ]
Huang, Yongkun [1 ]
机构：
[1] Kunming Med Univ, Dept Pediat, Affiliated Hosp 1, 295 Xichang Rd, Kunming 650032, Yunnan, Peoples R China
[2] Kunming Med Univ, Dept Stat, Sch Publ Hlth, Kunming 650000, Yunnan, Peoples R China
[3] Yunnan Ctr Dis Control & Prevent, 158 Dongsi St, Kunming 650022, Yunnan, Peoples R China
[4] Kunming Med Univ, Dept Clin Lab, Affiliated Hosp 1, Kunming 650032, Yunnan, Peoples R China
来源：
BMC PEDIATRICS | 2022年 / 22卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Gut microbiota; Children development; Microbial metabolism; Bile acids; Short chain fatty acids; CHAIN FATTY-ACIDS; GASTROINTESTINAL MICROBIOME; HEALTH; HOST; DISEASE; IMPACT;
D O I：
10.1186/s12887-021-03099-9
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Background: To reveal the changes of intestinal microbial abundance and composition, as well as the microbiota metabolic levels of bile acids and short chain fatty acids of healthy preschool children during their growth. Methods: Feces of 120 healthy newborns and 150 healthy children aged 6 months to 6 years were collected. Then the composition of intestinal flora was analyzed by 16S rRNA, and the contents of bile acids and short chain fatty acids in feces were detected by LC-MS and GS methods, respectively. Results: The composition and function of intestinal microflora were not stable in neonatal period but significantly improved at 6 months after birth, and gradually stabilized and tended to adult-like formation after 2-3 years old. The levels of short chain fatty acids and secondary bile acids were consistent with the development of gut microbiota. Conclusion: The age of 6 months may be a critical period for the development of intestinal microflora in children.
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页数：11
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