Zoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effects in Neuroinflammation

被引：12
|
作者：
Guillen, Paul O. [1 ,2 ,3 ]
Gegunde, Sandra [4 ]
Jaramillo, Karla B. [1 ,3 ,5 ]
Alfonso, Amparo [4 ]
Calabro, Kevin [2 ,3 ]
Alonso, Eva [4 ]
Rodriguez, Jenny [1 ]
Botana, Luis M. [4 ]
Thomas, Olivier P. [2 ,3 ]
机构：
[1] ESPOL, ESPOL Escuela Super Politecn Litoral, Ctr Nacl Acuacultura & Invest Marinas, Campus Gustavo Galindo Km 30-5 Via Perimetral, Guayaquil, Ecuador
[2] Natl Univ Ireland Galway, Marine Biodiscovery, Sch Chem, Univ Rd, Galway H91 TK33, Ireland
[3] Natl Univ Ireland Galway, Ryan Inst, Univ Rd, Galway H91 TK33, Ireland
[4] Univ Santiago de Compostela, Fac Vet, Dept Farmacol, Lugo 27002, Spain
[5] Natl Univ Ireland Galway, Zool, Sch Nat Sci, Galway H91 TK33, Ireland
来源：
MARINE DRUGS | 2018年 / 16卷 / 07期
基金：
欧盟地平线“2020”;
关键词：
zoantharia; Tropical Eastern Pacific; Zoanthus pulchellus; zoanthamine; inflammation; MARINE ZOANTHID; NORZOANTHAMINE; CYCLIZATION;
D O I：
10.3390/md16070242
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new zoanthamine alkaloids, namely 3-acetoxynorzoanthamine (1) and 3-acetoxyzoanthamine (2), have been isolated from the zoantharian Zoanthus cf. pulchellus collected off the coast of the Santa Elena Peninsula, Ecuador, together with three known derivatives: zoanthamine, norzoanthamine, and 3-hydroxynorzoanthamine. The chemical structures of 1 and 2 were determined by interpretation of their 1D and 2D NMR data and comparison with literature data. This is the first report of zoanthamine-type alkaloids from Zoanthus cf. pulchellus collected in the Tropical Eastern Pacific. The neuroinflammatory activity of all the isolated compounds was evaluated in microglia BV-2 cells and high inhibitory effects were observed in reactive oxygen species (ROS) and nitric oxide (NO) generation.
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页数：10
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