Z-Selective Olefin Metathesis Reactions Promoted by Tungsten Oxo Alkylidene Complexes

被引：106

作者：

Peryshkov, Dmitry V. ^{[1
]}

Schrock, Richard R. ^{[1
]}

Takase, Michael K. ^{[1
]}

Mueller, Peter ^{[1
]}

Hoveyda, Arnir H. ^{[2
]}

机构：

[1] MIT, Dept Chem 6 331, Cambridge, MA 02139 USA

[2] Boston Coll, Dept Chem, Merkert Chem Ctr, Chestnut Hill, MA 02467 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 51期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

METAL-CARBON BONDS; METALLACYCLOBUTANE COMPLEXES; TANTALUM COMPLEXES; CATALYSTS; MOLYBDENUM; REACTIVITY; MO; B(C6F5)(3); PRECURSORS; NIOBIUM;

D O I：

10.1021/ja210349m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Addition of LiOHMT (OHMT = O-2,6-dimesitylphenoxide) to W(O)(CH-t-Bu)(PMe2Ph)(2)Cl-2 led to WO(CH-t-Bu)Cl(OHMT)(PMe2Ph) (4). Subsequent addition of Li(2,5-Me2C4H2N) to 4 yielded yellow W(O)(CH-t-Bu)(OHMT)(Me(2)Pyr)(PMe2Ph) (5). Compound 5 is a highly effective catalyst for the Z-selective coupling of selected terminal olefins (at 0.2% loading) to give product in >75% yield with >99% Z configuration. Addition of 2 equiv of B(C6F5)(3) to 5 afforded a catalyst activated at the oxo ligand by B(C6F5)(3). 5.B(C6F5)(3) is a highly active catalyst that produces thermodynamic products (similar to 20% Z).

引用

页码：20754 / 20757

页数：4

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