Chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation of 3-trifluoromethylthioquinolines

被引：18
|
作者：
Zhou, Ji [1 ]
Zhang, Qian-Fan [1 ]
Zhao, Wei-Hao [1 ]
Jiang, Guo-Fang [1 ]
机构：
[1] Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 29期
基金：
中国国家自然科学基金;
关键词：
ENANTIOSELECTIVE TRANSFER HYDROGENATION; ORGANOCATALYTIC TRANSFER HYDROGENATION; ALPHA-FLUORINATED ETHERS; METHIONINE GAMMA-LYASE; BRONSTED ACID; HANTZSCH ESTERS; REDUCTIVE AMINATION; HETEROAROMATIC-COMPOUNDS; IN-VITRO; QUINOLINES;
D O I：
10.1039/c6ob01176d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation of 3-trifluoromethylthioquinolines has been successfully developed, providing direct and facile access to chiral 2,3-disubstituted 1,2,3,4-tetrahydroquinoline derivatives containing a stereogenic trifluoromethylthio group with up to 99% enantioselectivity.
引用
收藏
页码：6937 / 6941
页数：5
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