Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases

被引：323

作者：

Sonnweber, Thomas ^{[1
]}

Pizzini, Alex ^{[1
]}

Nairz, Manfred ^{[1
]}

Weiss, Guenter ^{[1
]}

Tancevski, Ivan ^{[1
]}

机构：

[1] Med Univ Innsbruck, Dept Internal Med 2, A-6020 Innsbruck, Austria

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 11期

关键词：

arachidonic acid; eicosanoids; metabolic disease; obesity; nonalcoholic fatty liver disease; diabetes; atherosclerosis; cardiovascular disease; cholesterol; FATTY LIVER-DISEASE; SOLUBLE EPOXIDE HYDROLASE; RECEPTOR ANTAGONIST MONTELUKAST; ASPIRIN-TRIGGERED LIPOXIN; LEUKOTRIENE B-4 RECEPTOR; INSULIN-RESISTANCE; EPOXYEICOSATRIENOIC ACIDS; MYOCARDIAL ISCHEMIA; OXIDATIVE STRESS; LIPID MEDIATORS;

D O I：

10.3390/ijms19113285

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipid and immune pathways are crucial in the pathophysiology of metabolic and cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to immunity and inflammation, thus holding a key role in the emergence and progression of frequent diseases such as obesity, diabetes, non-alcoholic fatty liver disease, and cardiovascular disease. We herein present a synopsis of AA metabolism in human health, tissue homeostasis, and immunity, and explore the role of the AA metabolome in diverse pathophysiological conditions and diseases.

引用

页数：26

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