Effect of Gluten-Free Diet on Growth and Glycemic Control in Children with Type 1 Diabetes and Asymptomatic Celiac Disease

被引:8
|
作者
Goh, Vi Lier [1 ,2 ]
Estrada, D. Elizabeth [1 ,2 ]
Lerer, Trudy [1 ,2 ]
Balarezo, Fabiola [3 ]
Sylvester, Francisco A. [1 ,2 ]
机构
[1] Connecticut Childrens Med Ctr, Hartford, CT 06106 USA
[2] Univ Connecticut, Sch Med, Farmington, CT USA
[3] Hartford Hosp, Hartford, CT 06115 USA
来源
关键词
celiac disease; diabetes mellitus; children; growth; gluten-free diet; PREVALENCE; MORTALITY; MELLITUS;
D O I
10.1515/jpem.2010.183
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We aimed to evaluate the effects of a gluten-free diet on growth and glycemic control in children with type 1 diabetes mellitus (DM) and asymptomatic, biopsy-proven celiac disease (CD). Each case of CD was compared to two children with DM and no CD. We studied weight, height, and hemoglobin A1c (HgbA1c) up to 12 months pre- and post- CD diagnosis in 29 cases and 58 controls. The change in body mass index (Delta BMI Z-score) over 2 years was significantly higher in CD cases vs. controls (mean +/- SD 0.33 +/- 0.74 vs. -0.08 +/- 0.46; p = 0.023). However, BMI Z-score did not change in CD patients diagnosed with DM for > 1 year. Mean HgbA1c was similar between groups throughout the study. In conclusion, children with asymptomatic CD and DM do not have significant changes in BMI, height Z-score or metabolic control 1 year post-diagnosis.
引用
收藏
页码:1169 / 1173
页数:5
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