Two New Drimane Sesquiterpenoids from Compound Changweikang and Their Inhibitory Activity against Nitric Oxide Production

被引：5

作者：

Liu, Ming-sheng ^{[1
,2
]}

Liu, Chang ^{[3
]}

Zhang, Xiao-po ^{[1
]}

Sheng, Lin ^{[1
,2
]}

Zhang, Jun-qing ^{[1
,2
]}

Kang, Sheng-li ^{[1
,2
]}

机构：

[1] Hainan Med Univ, Sch Pharmaceut Sci, Haikou 571101, Peoples R China

[2] Hainan Prov Key Lab R&D Trop Herbs, Haikou 571101, Peoples R China

[3] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 09期

关键词：

compound Changweikang; Daphniphyllum calycinum; Polygonum hydropiper; changweikangic acid A; changweikangic acid B; nitric oxide production;

D O I：

10.1248/cpb.58.1224

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new drimane sesquiterpenoids, changweikangic acid A (1) and B (2), were isolated from Compound Changweikang. Their structures were established on basis of extensive spectroscopic analyses including two dimensional (2D) NMR and X-ray crystallographic data. The two compounds were evaluated for their inhibitory activity against nitric oxide production in lipopolysaccharide-activated macrophage cell line, RAW 264.7 cells.

引用

页码：1224 / 1226

页数：3

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