Transgenic models and subcellular pathology - do they tell us what goes wrong in Huntington's disease?

被引：3
|
作者：
Reynolds, GP [1 ]
Dalton, CF [1 ]
机构：
[1] Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, England
来源：
MOLECULAR PSYCHIATRY | 1998年 / 3卷 / 03期
关键词：
D O I：
10.1038/sj.mp.4000374
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Studies of a transgenic mouse model of Huntington's disease have led to the identification of protein deposits in neuronal nuclei in CAG repeat expansion diseases. The relationship between neuropathology and these nuclear inclusions points to their possible role in pathogenesis.
引用
收藏
页码：192 / 195
页数：4
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