The associations of BMI with mean diffusivity of basal ganglia among young adults with mild obesity and without obesity

被引：6

作者：

Takeuchi, Hikarua ^{[1
]}

Taki, Yasuyuki ^{[1
,2
,3
]}

Nouchi, Rui ^{[4
,5
,6
]}

Yokoyama, Ryoichi ^{[7
]}

Nakagawa, Seishu ^{[8
,9
]}

Iizuka, Kunio ^{[9
]}

Sakaki, Kohei ^{[6
]}

Araki, Tsuyoshi ^{[10
]}

Nozawa, Takayuki ^{[11
]}

Ikeda, Shigeyuki ^{[12
]}

Yokota, Susumu ^{[1
]}

Hanawa, Sugiko ^{[8
]}

Magistro, Daniele ^{[13
]}

Kotozaki, Yuka ^{[14
]}

Sasaki, Yukako ^{[6
]}

Kawata, Kelssy H. dos S. ^{[15
]}

Kawashima, Ryuta ^{[1
,4
,6
]}

机构：

[1] Tohoku Univ, Inst Dev Aging & Canc IDAC, Div Dev Cognit Neurosci, Aoba Ku, 4-1 Seiryo Cho, Sendai, Miyagi 9808575, Japan

[2] Tohoku Univ, Dept Community Med Supports, Div Med Neuroimaging Anal, Tohoku Med Megabank Org, Sendai, Miyagi, Japan

[3] Tohoku Univ, Inst Dev Aging & Canc, Dept Radiol & Nucl Med, Sendai, Miyagi, Japan

[4] Tohoku Univ, Frontier Res Inst Interdisciplinary Sci, Creat Interdisciplinary Res Div, Sendai, Miyagi, Japan

[5] Tohoku Univ, Int Res Inst Disaster Sci, Human & Social Response Res Div, Sendai, Miyagi, Japan

[6] Tohoku Univ, Inst Dev Aging & Canc, Dept Adv Brain Sci, Sendai, Miyagi, Japan

[7] Kobe Univ, Sch Med, Kobe, Hyogo, Japan

[8] Tohoku Univ, Inst Dev Aging & Canc, Dept Human Brain Sci, Sendai, Miyagi, Japan

[9] Tohoku Med & Pharmaceut Univ, Div Psychiat, Sendai, Miyagi, Japan

[10] ADVANTAGE Risk Management Co Ltd, Tokyo, Japan

[11] Tokyo Inst Technol, Collaborat Res Ctr Happiness Cocreat Soc Intellig, Tokyo, Japan

[12] Tohoku Univ, Inst Dev Aging & Canc, Dept Ubiquitous Sensing, Sendai, Miyagi, Japan

[13] Loughborough Univ, Natl Ctr Sport & Exercise Med NCSEM, NIHR Leicester Loughborough Diet Lifestyle & Phys, Sch Sport Exercise & Hlth Sci, Loughborough, Leics, England

[14] Fukushima Med Univ, Med Ind Translat Res Ctr, Div Clin Res, Sch Med, Fukushima, Japan

[15] Univ Tokyo, Ctr Evolutionary Cognit Sci, Tokyo, Japan

来源：

SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期

关键词：

BODY-MASS INDEX; MATTER VOLUME; DOPAMINE; BRAIN; MOOD; SYSTEM; REWARD; ACTIVATION; OVERWEIGHT; MOTIVATION;

D O I：

10.1038/s41598-020-69438-5

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Obesity causes a wide range of systemic diseases and is associated with mood and anxiety disorders. It is also associated with dopaminergic reward system function. However, the relationships between microstructural properties of the dopaminergic system and body mass index (BMI) have not been investigated. In this study, we investigated the associations of BMI with mean diffusivity (MD), diffusion tensor imaging measure in areas of the dopaminergic system (MDDS) in 435 healthy young adults with mild obesity and without obesity (BMI<40). We detected the association between greater BMI and lower MD of the right globus pallidus and the right putamen. These results suggest that the property of the dopaminergic system is associated with BMI among young adults with mild obesity and without obesity.

引用

页数：8

共 50 条

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Hikarua Takeuchi
Yasuyuki Taki
Rui Nouchi
Ryoichi Yokoyama
Seishu Nakagawa
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Shigeyuki Ikeda
Susumu Yokota
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Yukako Sasaki
Kelssy H. dos S. Kawata
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[J]. Scientific Reports, 10
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