Mild, efficient, selective and "green" benzoylation of nucleosides using benzoyl cyanide in ionic liquid

被引：2
|
作者：
Prasad, AK [1 ]
Kumar, V
Maity, J
Sanghvi, YS
Ravikumar, VT
Parmar, VS
机构：
[1] Univ Delhi, Dept Chem, Bioorgan Lab, Delhi 110007, India
[2] Isis Pharmaceut Inc, Carlsbad, CA USA
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2005年 / 24卷 / 5-7期
关键词：
D O I：
10.1081/NCN-200060065
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Use of benzoyl cyanide (BzCN) for benzoylation Of nucleasides has been studied, both in pyridine and in ionic liquid. BzCN in 1-methoxyethyl-3-methylimidazolium methanesulfonate as ionic liquid has been found to be a "green" alternative compared to the pyridine-BzCN system An efficient and selective benzoylation of nucleosides of both, the 2'-deoxy- and the ribo-series at ambient temperature was accomplished.
引用
收藏
页码：747 / 751
页数：5
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