The role of the randomized controlled trial in plastic surgery

被引：21

作者：

Thoma, Achilleas ^{[1
,2
,3
]}

Sprague, Sheila ^{[1
]}

Temple, Claire ^{[4
]}

Archibald, Stuart ^{[3
,5
]}

机构：

[1] McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON L8L 8E7, Canada

[2] McMaster Univ, Div Plast Surg, Dept Surg, Hamilton, ON L8N 4A6, Canada

[3] McMaster Univ, SOURCE, Hamilton, ON L8N 4A6, Canada

[4] Univ Western Ontario, Hand & Upper Limb Ctr, St Josephs Hlth Ctr, London, ON N6A 4L6, Canada

[5] McMaster Univ, Div Head & Neck Surg, Dept Surg, Hamilton, ON L8N 4A6, Canada

来源：

CLINICS IN PLASTIC SURGERY | 2008年 / 35卷 / 02期

关键词：

D O I：

10.1016/j.cps.2007.10.011

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

This article discusses the role of the randomized controlled trial (RCT) in plastic surgery. There are unique challenges in the execution of an RCT in plastic surgery; including: (1) surgical equipoise, (2) the surgical learning curve, (3) differential care, (4) randomization, (5) concealment, (6) expertise-based design, (7) blinding, (8) intention-to-treat analysis, (9) loss to follow-up, and (10) treatment effect and implications for sample size calculations. The RCTs conducted in plastic surgery to date are generally of poor quality in design and reporting, are fraught with bias, and have small sample sizes, thus this article attempts to help future investigators perform better quality RCTs.

引用

页码：275 / +

页数：11

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