Azithromycin Susceptibility Among Neisseria gonorrhoeae Isolates and Seasonal Macrolide Use

被引：31
|
作者：
Olesen, Scott W. [1 ]
Torrone, Elizabeth A. [4 ]
Papp, John R. [4 ]
Kirkcaldy, Robert D. [4 ]
Lipsitch, Marc [1 ,2 ]
Grad, Yonatan H. [1 ,3 ]
机构：
[1] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA USA
[2] Harvard TH Chan Sch Publ Hlth, Ctr Communicable Dis Dynam, Boston, MA USA
[3] Harvard Med Sch, Brigham & Womens Hosp, Div Infect Dis, Boston, MA 02115 USA
[4] Ctr Dis Control & Prevent, Div STD Prevent, Atlanta, GA USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2019年 / 219卷 / 04期
关键词：
Gonorrhea; antibiotic resistance; azithromycin; seasons; UNITED-STATES; RESISTANCE; PRESCRIPTION; SURVEILLANCE;
D O I：
10.1093/infdis/jiy551
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Rising azithromycin nonsusceptibility among Neisseria gonorrhoeae isolates threatens current treatment recommendations, but the cause of this rise is not well understood. We performed an ecological study of seasonal patterns in macrolide use and azithromycin resistance in N. gonorrhoeae, finding that population-wide macrolide use is associated with increased azithromycin nonsusceptibility. These results, indicative of bystander selection, have implications for antibiotic prescribing guidelines.
引用
收藏
页码：619 / 623
页数：5
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